State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100176, China.
Sci China Life Sci. 2010 Nov;53(11):1284-90. doi: 10.1007/s11427-010-4089-y. Epub 2010 Nov 3.
Gram-negative, facultative intracellular anaerobes of the genus Shigella, the principal etiologic agents of shigellosis, continue to pose a threat to public health. Shigellosis causes 1.1 million deaths with over 164 million annual cases. The Shigella spp. can be divided into four serogroups: Shigella dysenteriae, Shigella flexneri, Shigella boydii and Shigella sonnei. The completion of seven Shigella genome sequences of representative strains from each of the Shigella species has introduced an era of whole-genome study. This paper reviews contemporary understanding of genomics, transcriptomics, proteomics and the structural biology of Shigella.
革兰氏阴性、兼性细胞内厌氧菌志贺氏菌属是志贺氏菌病的主要病原体，继续对公共卫生构成威胁。志贺氏菌病导致 110 万人死亡，每年有超过 1.64 亿例病例。志贺氏菌可分为四个血清群：痢疾志贺菌、福氏志贺菌、鲍氏志贺菌和宋内志贺菌。完成了来自每种志贺菌的 7 个代表性菌株的全基因组序列，开创了全基因组研究的时代。本文综述了当代对志贺氏菌基因组学、转录组学、蛋白质组学和结构生物学的理解。
