Ji Xing-yue, Zhong Zhao-jin, Xue Si-tu, Meng Shuai, He Wei-ying, Gao Rong-mei, Li Yu-huan, Li Zhuo-rong
Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People’s Republic of China.
Chem Pharm Bull (Tokyo). 2010 Nov;58(11):1436-41. doi: 10.1248/cpb.58.1436.
A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (Cox B3), 10 and 6f against influenza virus A (influenza A) and 7a against herpes simplex virus 2 (HSV-2). However, most of the synthetic glutarimides showed comparatively much weaker activity against influenza A, Cox B3 and HSV-2 than the natural glutarimide compounds tested. Based on the results, it seemed likely that a conjugated system at the β-substituted moiety provides stronger antiviral activity.
合成了一系列新型戊二酰亚胺化合物，并评估了它们的抗病毒活性。表现出最强抗病毒活性的化合物包括针对柯萨奇病毒B3（Cox B3）的5、6f、7e和9，针对甲型流感病毒（甲型流感）的10和6f，以及针对单纯疱疹病毒2（HSV-2）的7a。然而，大多数合成戊二酰亚胺对甲型流感、Cox B3和HSV-2的活性比对测试的天然戊二酰亚胺化合物弱得多。基于这些结果，β-取代部分的共轭体系似乎可能提供更强的抗病毒活性。
