直截了当的三唑并环核苷酸膦酸酯的合成作为潜在的 HCV 抑制剂。
Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors.
机构信息
Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM1-UM2, Université Montpellier II, Montpellier, France.
出版信息
Bioorg Med Chem Lett. 2010 Dec 15;20(24):7365-8. doi: 10.1016/j.bmcl.2010.10.046. Epub 2010 Oct 16.
PMID:21051229
Abstract
Preparation of several triazoloacyclic nucleoside phosphonates is described. The key step of the synthesis involves a copper(I)-catalysed azide-alkyne 1,3-dipolar cycloaddition between azidoalkylphosphonates and propargylated nucleobases. The antiviral properties of these new analogues have been evaluated and revealed interesting potencies.
摘要
描述了几种三唑并环化核苷膦酸酯的制备方法。该合成的关键步骤涉及叠氮烷基膦酸酯与炔丙基化核苷之间的铜（I）催化的叠氮-炔 1,3-偶极环加成反应。这些新类似物的抗病毒性质已得到评估，并显示出有趣的效力。
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