Nephrology Division, Department of Medicine, Akdeniz University Medical School, Antalya, Turkey.
Nephrol Dial Transplant. 2011 Jun;26(6):1862-71. doi: 10.1093/ndt/gfq656. Epub 2010 Nov 4.
Chronic kidney disease (CKD) is a growing health problem worldwide that leads to end-stage kidney failure and cardiovascular complications. We aimed to determine the prevalence of CKD in Turkey, and to evaluate relationships between CKD and cardiovascular risk factors in a population-based survey.
Medical data were collected through home visits and interviews. Serum creatinine, blood glucose, total cholesterol, triglycerides, HDL, LDL and uric acid were determined from 12-h fasting blood samples, and spot urine tests were performed for subjects who gave consent to laboratory evaluation.
A total of 10 872 participants were included in the study. The final analysis was performed on 10 748 subjects (mean age 40.5 ± 16.3 years; 55.7% women) and excluded 124 pregnant women. A low glomerular filtration rate (GFR) (< 60 mL/min/1.73 m(2)) was present in 5.2% of the subjects who were evaluated for GFR, while microalbuminuria and macroalbuminuria were observed in 10.2% and 2% of the subjects, respectively. The presence of CKD was assessed in subjects who gave consent for urinary albumin excretion measurement (n = 8765). The overall prevalence of CKD was 15.7%; it was higher in women than men (18.4% vs. 12.8%, P < 0.001) and increased with increasing age of the subjects. The prevalence of hypertension (32.7% in the general population), diabetes (12.7%), dyslipidaemia (76.3%), obesity (20.1%) and metabolic syndrome (31.3%) was significantly higher in subjects with CKD than subjects without CKD (P < 0.001 for all).
The prevalence of CKD in Turkey is 15.7%. Cardiovascular risk factors were significantly more prevalent in CKD patients.
慢性肾脏病（CKD）是全球日益严重的健康问题，可导致终末期肾衰竭和心血管并发症。我们旨在确定土耳其 CKD 的患病率，并在一项基于人群的调查中评估 CKD 与心血管危险因素之间的关系。
通过家访和访谈收集医学数据。从 12 小时禁食的血液样本中测定血清肌酐、血糖、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和尿酸，对于同意进行实验室评估的受试者进行随机尿液检测。
共有 10872 名参与者纳入研究。最终分析纳入 10748 名受试者（平均年龄 40.5 ± 16.3 岁；55.7%为女性），排除 124 名孕妇。对接受肾小球滤过率（GFR）评估的受试者中，有 5.2%的 GFR 较低（<60mL/min/1.73m2），分别有 10.2%和 2%的受试者出现微量白蛋白尿和大量白蛋白尿。在同意进行尿白蛋白排泄测量的受试者中评估 CKD 的存在（n=8765）。CKD 的总体患病率为 15.7%；女性高于男性（18.4%比 12.8%，P<0.001），且随受试者年龄的增加而增加。CKD 患者的高血压（普通人群中为 32.7%）、糖尿病（12.7%）、血脂异常（76.3%）、肥胖（20.1%）和代谢综合征（31.3%）的患病率显著高于无 CKD 患者（所有 P<0.001）。
土耳其 CKD 的患病率为 15.7%。心血管危险因素在 CKD 患者中更为普遍。
Zotero 插件
