皮肤黑色素瘤中无默克尔细胞多瘤病毒。

Absence of merkel cell polyoma virus in cutaneous melanoma.

出版信息

Exp Dermatol. 2011 Jan;20(1):78-9. doi: 10.1111/j.1600-0625.2010.01175.x. Epub 2010 Nov 5.

DOI:10.1111/j.1600-0625.2010.01175.x

Abstract

Recently, merkel cell polyoma virus (MCPyV) has been described in 80% of merkel cell carcinomas (MCC). Similar to MCC, melanoma incidence is increased in immuno-suppressed patients. We hypothesized that MCPyV may play a role in melanoma development as well. We selected 95 archival, paraffin-embedded primary melanomas. DNA was obtained from micro-dissected tissue and amplified with PCR primer sets specific for the MCPyV T-antigen locus (LT1 and LT3) and for the VP1 gene. None of the 95 melanoma samples did show LT1, LT3, or VP1 fragment amplification. In conclusion, there is no evidence that MCPyV infection plays a role in cutaneous melanoma development.

摘要

最近，默克尔细胞多瘤病毒（MCPyV）已在 80%的默克尔细胞癌（MCC）中被描述。与 MCC 类似，免疫抑制患者的黑色素瘤发病率增加。我们假设 MCPyV 也可能在黑色素瘤的发展中起作用。我们选择了 95 例存档的石蜡包埋原发性黑色素瘤。从微切割组织中获得 DNA，并使用针对 MCPyV T 抗原基因座（LT1 和 LT3）和 VP1 基因的 PCR 引物对进行扩增。95 个黑色素瘤样本均未显示 LT1、LT3 或 VP1 片段扩增。总之，没有证据表明 MCPyV 感染在皮肤黑色素瘤的发展中起作用。