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澳大利亚腹主动脉瘤住院率和死亡率的下降。

Falling rates of hospitalization and mortality from abdominal aortic aneurysms in Australia.

机构信息

School of Surgery, University of Western Australia, Perth, Western Australia, Australia.

出版信息

J Vasc Surg. 2011 Feb;53(2):274-7. doi: 10.1016/j.jvs.2010.08.087. Epub 2010 Nov 4.

Abstract

BACKGROUND

Studies of the population trends for abdominal aortic aneurysms (AAAs) in the period 1970 to 2000 all indicated that the incidence of AAAs was increasing. It is not known whether this increase has continued. We hypothesized that the incidence of AAAs has begun to fall in Australia.

METHODS

Age-standardized national trends in mortality from AAAs were estimated for the period 1999 to 2006, and hospital separations (deaths or discharges) for AAAs were estimated for the period 1999 to 2008. Poisson regression models were constructed to estimate the relative change over time.

RESULTS

The age-standardized mortality rate from AAAs fell by an average of 6.0% (95% confidence interval [CI], 4.7-7.3) per annum in men and 2.9% (95% CI, 1.0-4.7) in women. After adjusting for age, hospital separations for men decreased by an average of 2.3% (95% CI, 1.4-2.7) per annum for nonruptured AAAs, and 5.9% (95% CI, 5.0-6.6) for ruptured AAAs and for women decreased by an average of 2.2% (95% CI, 1.4-3.0) per annum for nonruptured AAAs, and 5.1% (95% CI, 3.7-6.5) for ruptured AAAs. Ruptured, compared with nonruptured, AAAs were proportionally more common in women compared with men. The age-specific trends in separations from hospital were all downward apart from nonruptured AAAs in individuals aged 80 years and over.

CONCLUSIONS

The rates of separation from hospital and mortality for AAAs in Australia have fallen since 1999. This suggests a true fall in incidence of AAAs. Although the reasons for this are unknown, it has implications for policy decisions about screening.

摘要

背景

1970 年至 2000 年期间的多项研究表明,腹主动脉瘤(AAA)的发病率呈上升趋势。目前尚不清楚这种增长是否仍在持续。我们假设澳大利亚的 AAA 发病率已开始下降。

方法

对 1999 年至 2006 年期间 AAA 死亡率的年龄标准化全国趋势进行了估计,并对 1999 年至 2008 年期间的 AAA 住院分离(死亡或出院)进行了估计。构建泊松回归模型以估计随时间的相对变化。

结果

男性 AAA 的年龄标准化死亡率平均每年下降 6.0%(95%置信区间[CI],4.7-7.3),女性每年下降 2.9%(95%CI,1.0-4.7)。调整年龄后,男性非破裂性 AAA 的住院分离率平均每年下降 2.3%(95%CI,1.4-2.7),破裂性 AAA 下降 5.9%(95%CI,5.0-6.6),女性非破裂性 AAA 每年下降 2.2%(95%CI,1.4-3.0),破裂性 AAA 下降 5.1%(95%CI,3.7-6.5)。与男性相比,女性破裂性 AAA 与非破裂性 AAA 相比更为常见。除 80 岁及以上个体的非破裂性 AAA 外,所有年龄组的住院分离趋势均呈下降趋势。

结论

自 1999 年以来,澳大利亚的 AAA 住院分离率和死亡率均有所下降。这表明 AAA 的发病率确实有所下降。尽管原因尚不清楚,但这对有关筛查的政策决策具有影响。

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