奥米斯塔特（壳聚糖）可在体内肝素化的实验动物模型中止血：一种主要外周血管损伤模型的实验研究。
Omni-Stat (Chitosan) arrests bleeding in heparinised subjects in vivo: an experimental study in a model of major peripheral vascular injury.
机构信息
Department of Cardiothoracic Surgery, Blackpool Victoria Hospital Whinney Heys Road, Blackpool, FY3 8NR, UK.
出版信息
Eur J Cardiothorac Surg. 2011 Jun;39(6):952-4. doi: 10.1016/j.ejcts.2010.09.037. Epub 2010 Nov 4.
OBJECTIVE
To explore the effectiveness of Omni-Stat (Chitosan) in a model of major haemorrhage in the presence of clotting dysfunction.
METHOD
A total of 12 major femoral artery bleeds in moderately heparinised swine treated with Omni-Stat (Chitosan) were compared with five control bleeds.
RESULTS
Haemostasis was successfully achieved at first treatment in 10 of 12 bleeds and at second treatment in the remaining two bleeds.
CONCLUSION
The study supports the evidence that Omni-Stat (Chitosan) acts independently of classical clotting pathways and should be effective in patients with clotting dysfunctions, who suffer major haemorrhage. It also suggests the potential for a role in cardiac surgery.
目的
探讨 Omni-Stat（壳聚糖）在存在凝血功能障碍的大出血模型中的疗效。
方法
对比使用 Omni-Stat（壳聚糖）和未使用 Omni-Stat（壳聚糖）的肝素中度抗凝处理后的 12 例大型股动脉出血猪模型，其中 10 例治疗 1 次成功止血，2 例治疗 2 次成功止血。
结论
该研究支持 Omni-Stat（壳聚糖）独立于经典凝血途径发挥作用的证据，并且应该对有凝血功能障碍的大出血患者有效。这也表明它在心脏手术中有潜在作用。
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