Department of Pathology, The Mount Sinai Medical Center, New York, NY 10029, USA.
Hum Pathol. 2011 Jan;42(1):18-24. doi: 10.1016/j.humpath.2010.05.022. Epub 2010 Nov 5.
Pancreatic intraepithelial neoplasia (PanIN) has been found in association with pancreatic ductal adenocarcinoma, intraductal papillary-mucinous neoplasm (IPMN), mucinous cystic neoplasm, and other pancreatic lesions, but the characteristics of PanINs associated with these lesions are not well characterized. In this study, 185 partial or total pancreatectomy specimens were collected, and 173 had complete slides for reviewed, which included 74 pancreatic ductal adenocarcinomas, 28 IPMNs, 7 mucinous cystic neoplasms, 44 other nonductal tumors, and 20 nontumorous lesions. Differences in grade, extent, and duct involvement among PanINs associated with different lesions were analyzed. Patients with PanINs were older than those without, regardless of associated tumor or lesions. No sex predilection was noted. PanINs were found in 89%, 96%, 86%, 64%, and 55% pancreata with ductal adenocarcinomas, IPMNs, mucinous cystic neoplasm, other nonductal tumors, and nontumorous lesions, respectively. PanIN 1 and 2 were commonly associated with all types of lesions, but high-grade PanIN 3 was more frequently associated with ductal adenocarcinomas. Ductal involvement of PanINs was more extensive in association with ductal adenocarcinomas than in any other types of pancreatic tumors or lesions. PanINs associated with pancreatic ductal adenocarcinomas affected both the main and branched ducts, whereas PanINs associated with other types of pancreatic tumors or lesions were mainly present in the branch ducts. No statistical differences were observed in distribution, extent, and grade of PanINs among IPMNs, mucinous cystic neoplasms, other nonductal tumors, and nontumorous lesions. Our study demonstrated a high concurrence between PanINs and other precancerous lesions and histologic features of PanINs associated with different pancreatic diseases.
胰腺上皮内瘤变 (PanIN) 与胰腺导管腺癌、导管内乳头状黏液性肿瘤 (IPMN)、黏液性囊性肿瘤和其他胰腺病变有关，但与这些病变相关的 PanIN 的特征尚未得到很好的描述。在这项研究中，收集了 185 份部分或全胰切除术标本，其中 173 份有完整的切片可供复查，包括 74 例胰腺导管腺癌、28 例 IPMN、7 例黏液性囊性肿瘤、44 例其他非导管性肿瘤和 20 例非肿瘤性病变。分析了与不同病变相关的 PanIN 在分级、范围和导管受累方面的差异。无论是否存在相关肿瘤或病变，患有 PanIN 的患者均比未患有 PanIN 的患者年龄更大。未观察到性别偏好。在有导管腺癌、IPMN、黏液性囊性肿瘤、其他非导管性肿瘤和非肿瘤性病变的胰腺中，分别发现 PanINs 的比例为 89%、96%、86%、64%和 55%。PanIN1 和 2 通常与所有类型的病变相关，但高级别 PanIN3 更常与导管腺癌相关。与导管腺癌相比，PanIN 累及导管的范围更广。与其他类型的胰腺肿瘤或病变相比，与胰腺导管腺癌相关的 PanIN 影响主支和分支导管，而与其他类型的胰腺肿瘤或病变相关的 PanIN 主要存在于分支导管中。在 IPMN、黏液性囊性肿瘤、其他非导管性肿瘤和非肿瘤性病变中，PanIN 的分布、范围和分级无统计学差异。我们的研究表明，PanIN 与其他癌前病变之间存在高度一致性，并且与不同胰腺疾病相关的 PanIN 的组织学特征也存在一致性。
