Critical Care Medicine Department, Neurocritical Care Medicine, St. John's Mercy Medical Center, St. Louis University, St Louis, MO, USA.
Am J Emerg Med. 2012 Jan;30(1):251.e1-2. doi: 10.1016/j.ajem.2010.09.035. Epub 2010 Nov 6.
Therapeutic hypothermia is recommended for comatose survivors of cardiac arrest. Therapeutic hypothermia ameliorates multiple pathophysiologic mechanisms involved in ischemia-reperfusion injury, which may occur after cardiac arrest and near-hanging. Therapeutic hypothermia has not been prospectively studied in near-hanging. Victims of near-hanging suffer from strangulation with cerebral ischemia and resultant reperfusion injury rather than a fatal cervical spine injury. We report a case where therapeutic hypothermia was applied to a comatose survivor of near-hanging. A 41-year-old man presented with coma following attempted suicide by hanging. The patient underwent 24 hours of mild therapeutic hypothermia. The patient was discharged without neurologic sequelae and a Modified Rankin Scale of 0 (back to his baseline status). We present a case where therapeutic hypothermia was used safely and successfully in a patient without cardiac arrest but still in coma after attempted suicide by hanging. No randomized controlled trials on therapeutic hypothermia for comatose survivors of near-hanging victims have been published. However, in the absence of better evidence, it seems reasonable to consider hypothermia treatment in comatose near-hanging victims until more evidence can be obtained.
治疗性低温疗法推荐用于心脏骤停后昏迷的幸存者。治疗性低温可改善与缺血再灌注损伤相关的多种病理生理机制,这种损伤可能发生在心脏骤停和近乎窒息之后。在近乎窒息的情况下,尚未对治疗性低温进行前瞻性研究。近乎窒息的受害者会因窒息导致脑缺血和再灌注损伤而受苦,而不是致命的颈椎损伤。我们报告了一例近乎窒息的昏迷幸存者接受治疗性低温治疗的病例。一名 41 岁男子因试图上吊自杀后出现昏迷。该患者接受了 24 小时的轻度治疗性低温治疗。患者出院时没有神经后遗症,改良 Rankin 量表评分为 0(回到基线状态)。我们报告了一例在没有心脏骤停但在试图上吊自杀后仍处于昏迷状态的患者中安全且成功使用治疗性低温的病例。尚无关于近乎窒息的昏迷幸存者接受治疗性低温治疗的随机对照试验。然而,在缺乏更好证据的情况下,在获得更多证据之前,似乎可以考虑对近乎窒息的昏迷受害者进行低温治疗。