6-Hydroxydopamine lesions of the olfactory tubercle do not alter (+)-amphetamine-conditioned place preference.
作者信息
Clarke P B, White N M, Franklin K B
机构信息
Department of Pharmacology and Therapeutics, McGill University, Montral, Canada.
出版信息
Behav Brain Res. 1990 Jan 1;36(1-2):185-8. doi: 10.1016/0166-4328(90)90173-c.
PMID:2105735
Abstract
Rats received bilateral infusions of 6-hydroxydopamine into the olfactory tubercle, resulting in a substantial (89%) local depletion of dopamine. This treatment did not significantly alter conditioned place preference produced by (+)-amphetamine, suggesting that the mesolimbic dopaminergic projection to olfactory tubercle does not mediate the rewarding effects of (+)-amphetamine in rats.
摘要
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