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6-Hydroxydopamine lesions of the olfactory tubercle do not alter (+)-amphetamine-conditioned place preference.

作者信息

Clarke P B, White N M, Franklin K B

机构信息

Department of Pharmacology and Therapeutics, McGill University, Montral, Canada.

出版信息

Behav Brain Res. 1990 Jan 1;36(1-2):185-8. doi: 10.1016/0166-4328(90)90173-c.

DOI:10.1016/0166-4328(90)90173-c
PMID:2105735
Abstract

Rats received bilateral infusions of 6-hydroxydopamine into the olfactory tubercle, resulting in a substantial (89%) local depletion of dopamine. This treatment did not significantly alter conditioned place preference produced by (+)-amphetamine, suggesting that the mesolimbic dopaminergic projection to olfactory tubercle does not mediate the rewarding effects of (+)-amphetamine in rats.

摘要

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