唐氏综合征患儿破伤风类毒素加强免疫后，亲和成熟受损。
Impaired avidity maturation after tetanus toxoid booster in children with Down syndrome.
机构信息
Department of Pediatrics, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
出版信息
Pediatr Infect Dis J. 2011 Apr;30(4):357-9. doi: 10.1097/INF.0b013e3181ff85a8.
PMID:21057373
Abstract
Down syndrome children show a decreased avidity of the antibody response after tetanus toxoid booster vaccination at 9 years of age suggesting impaired memory B cell selection in the germinal center. Clinicians need to be aware of this ongoing subtle immunologic deficit in Down syndrome.
摘要
唐氏综合征儿童在 9 岁时进行破伤风类毒素加强疫苗接种后，抗体反应的亲和力降低，表明生发中心中记忆 B 细胞选择受损。临床医生需要意识到唐氏综合征患者存在持续存在的这种微妙的免疫缺陷。
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