[黑腹果蝇中ss基因与CG5017基因在肢体形态发生调控中的相互作用]

[Interaction of the ss and CG5017 genes in the regulation of morphogensis of limbs in Drosophila melanogaster].

作者信息

Kuzin B A, Modestova E A, Vorontsova Iu E, Zatsepina O G, Mikaelian A S, Slezinger M V, Simonova O B

出版信息

Ontogenez. 2010 Sep-Oct;41(5):364-9.

Abstract

The influence of the P-element built into the area of the CG5017 gene on the mutation of the spineless (ss) gene was studied. It was shown that the insertion of the P-element decreased the level of transcription of CG5017 approximately twofold. Modulation of the level of transcription of the CG5017 gene helped demonstrate, for the first time, its influence on the phenotypic manifestation of the mutation of the ss gene, which shows their interaction in the process of regulation of morphogenesis of limbs in Drosophila melanogaster.

摘要

研究了插入到CG5017基因区域的P因子对无脊椎（ss）基因变异的影响。结果表明，P因子的插入使CG5017的转录水平降低了约两倍。CG5017基因转录水平的调节首次有助于证明其对ss基因突变表型表现的影响，这表明它们在黑腹果蝇肢体形态发生调控过程中相互作用。