Miettinen A, Heinonen P K, Teisala K, Hakkarainen K, Punnonen R
Department of Biomedical Sciences, University of Tampere, Finland.
Sex Transm Dis. 1990 Jan-Mar;17(1):10-4.
The authors used enzyme immunoassay to determine the prevalence of serum antibodies to the sexually transmitted disease (STD) organisms Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma hominis among 104 infertile women undergoing in vitro fertilization. Altogether, 55 (72%) out of 76 women with tubal abnormalities tested positive for one or more STD organisms, compared with only 6 (21%) out of 28 infertile women with normal tubes (P less than .001). The authors obtained positive test results for C. trachomatis, N. gonorrhoeae, and M. hominis in 40%, 14%, and 37% of the patients with tubal abnormalities, respectively; of women without tubal abnormalities, the test results were 7%, 0%, and 14%, respectively. Out of 20 patients with a history of ectopic pregnancy, the authors obtained positive findings for C. trachomatis, N. gonorrhoeae, and M. hominis in 8 (40%), 1 (5%), and 7 (35%), respectively. These results indicate an independent role for all three STD organisms in the etiology of tubal factor infertility and ectopic pregnancy following both symptomatic and asymptomatic pelvic inflammatory disease (PID). The correlation between positive mycoplasmal serology and secondary infertility and tubal abnormalities may suggest a link between M. hominis infections during pregnancy and delivery complications and consequent development of tubal factor infertility.
作者采用酶免疫测定法，对104名接受体外受精的不孕女性血清中针对性传播疾病（STD）病原体沙眼衣原体、淋病奈瑟菌和人型支原体的抗体流行情况进行了测定。在76名有输卵管异常的女性中，共有55名（72%）检测出一种或多种STD病原体呈阳性，相比之下，28名输卵管正常的不孕女性中只有6名（21%）呈阳性（P小于0.001）。作者分别在40%、14%和37%的输卵管异常患者中检测到沙眼衣原体、淋病奈瑟菌和人型支原体呈阳性；在无输卵管异常的女性中，检测结果分别为7%、0%和14%。在20名有宫外孕病史的患者中，作者分别在8名（40%）、1名（5%）和7名（35%）患者中检测到沙眼衣原体、淋病奈瑟菌和人型支原体呈阳性。这些结果表明，这三种STD病原体在有症状和无症状盆腔炎（PID）后的输卵管因素不孕和宫外孕病因中均起独立作用。支原体血清学阳性与继发性不孕和输卵管异常之间的相关性可能提示孕期和分娩并发症期间人型支原体感染与随后输卵管因素不孕的发生之间存在联系。
