一个世纪的多效性：回顾
One hundred years of pleiotropy: a retrospective.
机构信息
Department of Biology, University of Maryland, College Park, Maryland 20742, USA.
出版信息
Genetics. 2010 Nov;186(3):767-73. doi: 10.1534/genetics.110.122549.
Abstract
Pleiotropy is defined as the phenomenon in which a single locus affects two or more distinct phenotypic traits. The term was formally introduced into the literature by the German geneticist Ludwig Plate in 1910, 100 years ago. Pleiotropy has had an important influence on the fields of physiological and medical genetics as well as on evolutionary biology. Different approaches to the study of pleiotropy have led to incongruence in the way that it is perceived and discussed among researchers in these fields. Furthermore, our understanding of the term has changed quite a bit since 1910, particularly in light of modern molecular data. This review traces the history of the term "pleiotropy" and reevaluates its current place in the field of genetics.
摘要
多效性是指单个基因座影响两个或更多不同表型特征的现象。100 年前，德国遗传学家路德维希·普拉特（Ludwig Plate）正式将该术语引入文献中。多效性对生理和医学遗传学以及进化生物学领域产生了重要影响。不同的多效性研究方法导致了这些领域的研究人员对其看法和讨论的不一致。此外，自 1910 年以来，我们对该术语的理解发生了很大变化，特别是在现代分子数据的背景下。本综述追溯了“多效性”一词的历史，并重新评估了它在遗传学领域的当前地位。
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本文引用的文献
1
Moonlighting proteins: an intriguing mode of multitasking.
Biochim Biophys Acta. 2010 Apr;1803(4):520-5. doi: 10.1016/j.bbamcr.2010.01.022. Epub 2010 Feb 6.
2
RNA editing: a driving force for adaptive evolution?
Bioessays. 2009 Oct;31(10):1137-45. doi: 10.1002/bies.200900045.
3
Antagonistic coevolution of two imprinted loci with pleiotropic effects.
Evolution. 2010 Jan;64(1):142-51. doi: 10.1111/j.1558-5646.2009.00826.x. Epub 2009 Aug 24.
4
A preliminary analysis of gene pleiotropy estimated from protein sequences.
J Exp Zool B Mol Dev Evol. 2010 Mar 15;314(2):115-22. doi: 10.1002/jez.b.21315.
5
Natural selection on pleiotropic quantitative trait Loci affecting a life-history trade-off in Avena barbata.
Evolution. 2009 Aug;63(8):2153-63. doi: 10.1111/j.1558-5646.2009.00701.x. Epub 2009 May 9.
6
Genetic architecture of quantitative traits in mice, flies, and humans.
Genome Res. 2009 May;19(5):723-33. doi: 10.1101/gr.086660.108.
7
What can genetic variation tell us about the evolution of senescence?
Proc Biol Sci. 2009 Jun 22;276(1665):2271-8. doi: 10.1098/rspb.2009.0183. Epub 2009 Mar 18.
8
Escape from adaptive conflict after duplication in an anthocyanin pathway gene.
Nature. 2008 Aug 7;454(7205):762-5. doi: 10.1038/nature07092. Epub 2008 Jun 25.
9
Pleiotropic scaling of gene effects and the 'cost of complexity'.
Nature. 2008 Mar 27;452(7186):470-2. doi: 10.1038/nature06756.
10
Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds.
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19387-91. doi: 10.1073/pnas.0708194104. Epub 2007 Nov 27.
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