原位聚合在口服给药系统设计与开发中的应用。
Application of in situ polymerization for design and development of oral drug delivery systems.
机构信息
Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
出版信息
AAPS PharmSciTech. 2010 Dec;11(4):1603-11. doi: 10.1208/s12249-010-9535-4. Epub 2010 Nov 11.
Abstract
Although preformed polymers are commercially available for use in the design and development of drug delivery systems, in situ polymerization has also been employed. In situ polymerization affords the platform to tailor and optimize the drug delivery properties of polymers. This review brings to light the benefits of in situ polymerization for oral drug delivery and the possibilities it provides to overcome the challenges of oral route of administration.
摘要
尽管已有商品化的预成型聚合物可用于药物传递系统的设计和开发，但原位聚合也已被应用。原位聚合赋予了调整和优化聚合物药物传递特性的平台。本文综述了原位聚合在口服药物传递中的优势，以及它为克服口服给药途径的挑战所提供的可能性。
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