Fayyaz Iram, Ahmed M Zamir, Shah Syed Imran, Mehmood Sadia, Akram Shama, Ghani Mansoor
Department of Biochemistry, CMH Lahore Medical College, Lahore, Pakistan.
J Ayub Med Coll Abbottabad. 2009 Oct-Dec;21(4):90-2.
Adiponectin is an adipocytokine secreted from white adipose tissue. Serum level of adiponectin has been shown to be reduced in several disease states like obesity and diabetes. Hypoadiponectinemia has also been included in the list of newer risk factors for Coronary Artery Disease (CAD).
In this analytical cross-sectional study serum adiponectin level was measured by Enzyme Linked Immunosorbant Assay (ELISA) in 60 cases of coronary artery disease (CAD) (both sexes, aged 40-60 yrs) and 60 healthy controls.
Low levels of adiponectin were seen in CAD patients as well as controls. These levels were lower as compared to western standards.
Our study conforms to the previous observation of lower serum adiponectin levels in South Asians compared to the western standards. Serum adiponectin level should be considered in the laboratory work-up of CAD patients.
脂联素是一种由白色脂肪组织分泌的脂肪细胞因子。在肥胖和糖尿病等多种疾病状态下，血清脂联素水平已被证明会降低。低脂联素血症也已被列入冠状动脉疾病（CAD）的新危险因素清单中。
在这项分析性横断面研究中，采用酶联免疫吸附测定法（ELISA）测量了60例冠状动脉疾病（CAD）患者（男女皆有，年龄40 - 60岁）和60名健康对照者的血清脂联素水平。
CAD患者和对照者中均观察到脂联素水平较低。与西方标准相比，这些水平更低。
我们的研究符合先前的观察结果，即与西方标准相比，南亚人的血清脂联素水平较低。在对CAD患者进行实验室检查时应考虑血清脂联素水平。
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