BUBR1 在口腔鳞状细胞癌中的表达及其与肿瘤分期和生存的关系。
BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival.
机构信息
Department of Pathology and Forensic Medicine, University of Trieste, Trieste, Italy.
出版信息
Head Neck. 2011 May;33(5):727-33. doi: 10.1002/hed.21532. Epub 2010 Nov 10.
BACKGROUND
Defects in the mitotic spindle checkpoint have been proposed to contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma (OSCC). BUBR1 is a key component of the spindle checkpoint, whose role in oral carcinogenesis still needs to be clarified.
METHODS
We have analyzed the expression of BUBR1 in 49 cases of OSCC by immunohistochemistry and compared the findings with clinicopathologic parameters, proliferative activity, and DNA ploidy.
RESULTS
BUBR1 was overexpressed in 11 cases (22.4%). Tumors with overexpression of BUBR1 were associated with a less advanced pathologic stage (p = .05) and showed longer survival periods (p = .38) but shorter recurrence-free survival periods (p = .13) than those without it.
CONCLUSIONS
Our data imply the possibility that BUBR1 may be involved in the progression of OSCC, and suggest that BUBR1 may be a promising prognostic marker in patients with OSCC.
背景
有研究提出，有丝分裂纺锤体检验点的缺陷可能导致人类癌症（包括口腔鳞状细胞癌，OSCC）中观察到的染色体不稳定性。BUBR1 是纺锤体检验点的一个关键组成部分，但其在口腔癌发生中的作用仍需要进一步阐明。
方法
我们通过免疫组织化学的方法，对 49 例 OSCC 中 BUBR1 的表达进行了分析，并将结果与临床病理参数、增殖活性和 DNA 倍性进行了比较。
结果
BUBR1 在 11 例（22.4%）中过表达。BUBR1 过表达的肿瘤具有更早期的病理分期（p=0.05）和更长的生存时间（p=0.38），但无复发生存时间更短（p=0.13）。
结论
我们的数据提示 BUBR1 可能参与了 OSCC 的进展，并表明 BUBR1 可能是 OSCC 患者有前途的预后标志物。
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