Anal Chem. 2010 Dec 1;82(23):9606-10. doi: 10.1021/ac1021503. Epub 2010 Nov 11.
We provide a highly sensitive and selective assay to detect Hg(2+) in aqueous solutions using gold nanoparticles modified with quaternary ammonium group-terminated thiols at room temperature. The mechanism is the abstraction of thiols by Hg(2+) that led to the aggregation of nanoparticles. With the assistance of solar light irradiation, the detection limit can be as low as 30 nM, which satisfies the guideline concentration of Hg(2+) in drinking water set by the WHO. In addition, the dynamic range of detection is wide (3 × 10(-8)-1 × 10(-2) M). This range, to our best knowledge, is the widest one that has been reported so far in gold nanoparticle (AuNP)-based assays for Hg(2+).
我们提供了一种高灵敏度和选择性的方法，可在室温下使用季铵基团终止的硫醇修饰的金纳米粒子检测水溶液中的 Hg(2+)。其原理是 Hg(2+)与硫醇的相互作用导致纳米粒子的聚集。在太阳光照射的辅助下，检测下限可低至 30 nM，这满足世界卫生组织规定的饮用水中 Hg(2+)的指导浓度。此外，检测范围很宽（3×10(-8)-1×10(-2) M）。据我们所知，这是迄今为止基于金纳米粒子 (AuNP) 检测 Hg(2+)的方法中报道的最宽的范围。
