von Willebrand disease.

The study of a wide variety of patients with vWD disorders has been extensive and intense over the last decade. In many instances the peculiarities of the expressions of the disorder have been critical in defining the underlying structure and function of vWF itself. As our knowledge of the biochemistry and physiology of vWF has grown, significant refinements in both diagnostic and therapeutic modalities have emerged that increasingly provide considerable benefit to the individual patient.