Anhui Medical University, School of Public Health, Department of Epidemiology and Biostatistics, 81 Meishan Road, Hefei, Anhui, 230032, PR China.
Expert Opin Ther Targets. 2011 Feb;15(2):119-26. doi: 10.1517/14728222.2011.534461. Epub 2010 Nov 12.
IL-19, IL-20 and IL-24 are members of the IL-10 family of cytokines, the human IL-19, IL-20 and IL-24 genes are all located on the q32 region of chromosome 1, and the three cytokines also share a common receptor IL-20R1/IL-20R2 heterodimer. These cytokines due to the similarity and shared receptor usage, are quite overlapping in function. Recently, the available evidence has indicated that interaction of these cytokines with their receptors might exhibit pro-inflammatory effects on autoimmune diseases, particularly psoriasis and rheumatoid arthritis. Since an imbalance between anti- and pro-inflammatory cytokines contribute to the development of autoimune diseases, these cytokines may be implicated in the pathogenesis of autoimmunity. In this paper, we concisely discuss the biological features of IL-19, IL-20 and IL-24, and focus on their potential roles in autoimmune diseases. Hopefully the information obtained will lead to a better understanding of the pathogenesis and development of novel therapeutic strategies for autoimmune diseases.
白细胞介素-19（IL-19）、白细胞介素-20（IL-20）和白细胞介素-24（IL-24）是白细胞介素-10 家族细胞因子的成员，人类的 IL-19、IL-20 和 IL-24 基因均位于染色体 1 的 q32 区域，这三种细胞因子也共享一个共同的受体 IL-20R1/IL-20R2 异二聚体。由于这些细胞因子具有相似性和共享的受体使用，因此在功能上相当重叠。最近，已有证据表明，这些细胞因子与其受体的相互作用可能对自身免疫性疾病，特别是银屑病和类风湿关节炎具有促炎作用。由于抗炎和促炎细胞因子之间的失衡导致自身免疫性疾病的发生，这些细胞因子可能与自身免疫的发病机制有关。本文简要讨论了 IL-19、IL-20 和 IL-24 的生物学特征，并重点介绍了它们在自身免疫性疾病中的潜在作用。希望获得的信息将有助于更好地理解自身免疫性疾病的发病机制和新的治疗策略的发展。
