Department of Gynecology and Obstetrics, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris VI, 75020 Paris, France.
Surg Oncol. 2011 Mar;20(1):e55-9. doi: 10.1016/j.suronc.2010.10.002. Epub 2010 Nov 11.
The sentinel lymph node (SLN) procedure is now used routinely for the staging of clinically node-negative patients with early breast cancer. Two identification techniques exist: colorimetric and isotopic. These can be used alone or in combination. The combined method is associated with an increased identification rate. However, allergic and adverse reactions to blue dyes have been reported. The objective of this review was to determine the incidence of such events and to discuss alternative approaches. The authors conducted a search of the MEDLINE and EMBASE databases for reports of anaphylactic responses to isosulfan blue dye and patent blue V dye. Allergic reaction to the dyes isosulfan blue and patent blue V is rare and the reported incidence varies between 0.07% and 2.7%. Methylene blue dye appears to be safer, with no cases of allergic events having been reported. However, allergy tests in some patients have proven that there is cross-reactivity between isosulfan blue dye and methylene blue dye. Even though the risk of an anaphylactic response is low, this raises questions about the usefulness of colorimetric detection of SLN and whether alternatives to the use of the isosulfan and patent blue V dyes, such as methylene blue, exist.
前哨淋巴结（SLN）检测程序现在被常规应用于临床淋巴结阴性的早期乳腺癌患者的分期。存在两种识别技术：比色法和同位素法。这些方法可以单独使用或联合使用。联合方法与更高的识别率相关。然而，已经报道了对蓝色染料过敏和不良反应的发生。本综述的目的是确定这些事件的发生率，并讨论替代方法。作者检索了 MEDLINE 和 EMBASE 数据库，以查找有关对异硫蓝染料和专利蓝 V 染料发生过敏反应的报告。对染料异硫蓝和专利蓝 V 的过敏反应很少见，报道的发生率在 0.07%至 2.7%之间。美兰染料似乎更安全，尚未有过敏事件的报道。然而，对一些患者的过敏测试表明，异硫蓝染料和美兰染料之间存在交叉反应。尽管过敏反应的风险较低，但这引发了对 SLN 比色检测的有效性以及是否存在异硫蓝和专利蓝 V 染料替代品（如美兰染料）的质疑。
