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[他汀类药物降低胆固醇治疗的药物经济学优化]

[Pharmaco-economic optimization of cholesterol-lowering treatment with statins].

作者信息

Ruiz García Antonio, Gordillo López Francisco Javier, Arranz Martínez Ezequiel, Hermosa Hernán Juan Carlos

机构信息

Unidad de Lípidos y Prevención Cardiovascular, Centro de Salud Pinto, Dirección Asistencial 4 SUR, SERMAS, Madrid, España.

出版信息

Med Clin (Barc). 2011 Jun 25;137(3):119-25. doi: 10.1016/j.medcli.2010.04.032. Epub 2010 Nov 12.

Abstract

Current guidelines for the management of hypercholesterolemia identify LDL cholesterol (LDL-c) reduction as the primary therapeutic target and have highlighted the need to use statins to achieve it. There are six statins with four different doses and with different power-reducing LDL-c. By adding ezetimibe, there are 48 therapeutic possibilities. This extensive offer provides pharmaceutical treatment, but it is difficult to choose the most cost-effective statin because it is very difficult to remember all the powers and costs of treatment options. This paper offers a method to prioritize the best cost-effective lipid lowering, and chooses the cheapest statin that achieves the desired therapeutic goal of LDL-c.

摘要

当前高胆固醇血症管理指南将降低低密度脂蛋白胆固醇(LDL-c)作为主要治疗目标,并强调使用他汀类药物来实现这一目标的必要性。有六种他汀类药物,有四种不同剂量且降低LDL-c的能力不同。通过添加依泽替米贝,有48种治疗方案。这种广泛的选择提供了药物治疗,但很难选择最具成本效益的他汀类药物,因为很难记住所有治疗方案的效力和成本。本文提供了一种方法来优先选择最具成本效益的降脂药物,并选择能够实现LDL-c所需治疗目标的最便宜的他汀类药物。

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