Macquarie Centre for Cognitive Science, Macquarie University, Sydney, Australia.
Exp Brain Res. 2011 Jan;208(2):189-201. doi: 10.1007/s00221-010-2470-5. Epub 2010 Nov 13.
Even the simplest volitional movements must be precisely coordinated with anticipatory postural adjustments. Little is currently known about the neural networks that coordinate these adjustments in healthy adults. We measured brain activity prior to movement during a bimanual load-lifting task, designed to elicit anticipatory adjustments in a restricted and well-defined set of musculature in the arm. Electroencephalography and magnetoencephalography brain measurements were obtained from eleven participants while they performed a bimanual load-lifting task that required precise inter-limb coordination. Anticipatory biceps brachii inhibition in the loaded arm was associated with a robust desynchronization of the beta rhythm. Beamforming analyses localized beta band responses to the parietal lobules, pre- and post-central gyri, middle and medial frontal gyri, basal ganglia and thalamus. The current study shows that premovement brain activity in a bimanual load-lifting task can be imaged with magnetoencephalography. Future experiments will partition out brain activity associated with anticipatory postural adjustments and volitional movements. The experimental paradigm will also be useful in the study of motor function in patients with developmental or degenerative disorders.
即使是最简单的意志运动也必须与预期的姿势调整精确协调。目前对于协调健康成年人这些调整的神经网络知之甚少。我们在一项双臂举重任务中测量了运动前的大脑活动，该任务旨在引起手臂受限且定义明确的一组肌肉的预期调整。当十一名参与者执行需要精确的肢体间协调的双臂举重任务时，我们获得了脑电图和脑磁图脑测量。受重手臂中的预期肱二头肌抑制与β节律的强烈去同步化有关。波束形成分析将β频带反应定位到顶叶小叶、中央前回和中央后回、中回和内回、基底神经节和丘脑。目前的研究表明，使用脑磁图可以对双臂举重任务中的运动前大脑活动进行成像。未来的实验将区分与预期姿势调整和自主运动相关的大脑活动。该实验范式对于研究发育或退行性疾病患者的运动功能也很有用。
