尿中凝血酶原片段 1 + 2 测定老年髋部骨折患者的凝血活性。
Coagulation activity in elderly patients with hip fracture measured by prothrombin fragment 1 + 2 in urine.
机构信息
Trauma Research Unit, Department of Orthopedics, Aarhus University Hospital, Aarhus, Denmark.
出版信息
Clin Appl Thromb Hemost. 2011 Nov-Dec;17(6):E52-6. doi: 10.1177/1076029610384111. Epub 2010 Nov 15.
OBJECTIVE
The purpose of this study was to document the uF1 + 2 excretion in elderly patients during and after a hip fracture (HF).
METHODS
The study was a prospective pilot study. Spot urine samples were collected immediately after admission and every morning until surgery. After surgery, urine samples were collected on days 1, 5, 7, 14, and at follow-up on day 90 (±10).
RESULTS
A total of 24 women and 7 men with HF completed the study. The median uF1 + 2 level was significantly increased on the day of admission relative to the median level at follow-up. Maximum levels were seen on day 1 with a decreasing tendency until follow-up. Patients treated with a hemiarthroplasty had higher median uF1 + 2 levels on all days compared with patients treated with osteosynthesis.
CONCLUSION
A substantial coagulation activity, indicated by high median levels of uF1 + 2, was seen at admission and during the first week after HF.
目的
本研究旨在记录髋部骨折（HF）患者在骨折期间和之后的 uF1 + 2 排泄情况。
方法
该研究为前瞻性试点研究。入院后立即和每天早上采集尿样，直至手术。手术后，在第 1、5、7、14 天和第 90 天（±10 天）进行随访时采集尿样。
结果
共有 24 名女性和 7 名男性 HF 患者完成了研究。与随访时的中位数相比，入院当天 uF1 + 2 水平显著升高。第 1 天达到最高水平，随后呈下降趋势直至随访。接受半髋关节置换术的患者在所有天数的 uF1 + 2 中位数水平均高于接受骨内固定术的患者。
结论
在入院和 HF 后第一周，可见到大量凝血活性，表明 uF1 + 2 中位数水平较高。
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