Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, PR China.
Int Immunopharmacol. 2011 May;11(5):536-42. doi: 10.1016/j.intimp.2010.11.008. Epub 2010 Nov 23.
FOXP3(+)CD4(+)CD25(+) Regulatory T (Treg) cells and IL-17 producing helper T cells (Th17) are critical subsets of T cells which play essential roles in immune homeostasis. The Forkhead family transcription factor FOXP3 is predominantly expressed in Treg cells, where the FOXP3 ensemble is essential for Treg cell development and function. As FOXP3 is to Treg cells, the orphan retinoic acid nuclear receptor (ROR) family transcription factor RORγt is essential for Th17 development and function. In this review, we summarize recent progress of our understanding towards the molecular mechanisms underlying the differentiation and function of FOXP3(+) Treg cells and RORγt expressing Th17 cells. These may provide new insights into therapeutic intervention and targeting of human immune-deficient diseases.
FOXP3(+)CD4(+)CD25(+) 调节性 T (Treg) 细胞和 IL-17 产生辅助性 T 细胞 (Th17) 是 T 细胞的关键亚群，在免疫稳态中发挥着重要作用。叉头框家族转录因子 FOXP3 主要在 Treg 细胞中表达，FOXP3 复合物对于 Treg 细胞的发育和功能至关重要。就像 FOXP3 对于 Treg 细胞一样，孤儿视黄酸核受体 (ROR) 家族转录因子 RORγt 对于 Th17 细胞的发育和功能至关重要。在这篇综述中，我们总结了我们对 FOXP3(+)Treg 细胞和表达 RORγt 的 Th17 细胞分化和功能的分子机制的最新理解。这些可能为人类免疫缺陷疾病的治疗干预和靶向提供新的思路。
