用于牙周组织再生的脂肪来源干细胞。

Adipose-derived stem cells for periodontal tissue regeneration.

作者信息

Tobita Morikuni, Mizuno Hiroshi

机构信息

Office of Surgeon General and Director of Medicine, Maritime Staff Office, Ministry of Defense, Tokyo, Japan.

出版信息

Methods Mol Biol. 2011;702:461-70. doi: 10.1007/978-1-61737-960-4_34.

DOI:10.1007/978-1-61737-960-4_34

PMID:21082423

Abstract

Mesenchymal stem cells can effectively regenerate destroyed periodontal tissue. Because periodontal tissues are complex, mesenchymal stem cells that can differentiate into many tissue types would aid periodontal tissue regeneration. Indeed, periodontal tissue regeneration using mesenchymal stem cells derived from adipose tissue or bone marrow has been performed in experimental animal models, such as rat, canine, swine, and monkey. We have shown that rat periodontal tissue can be regenerated with adipose-derived stem cells. Adipose tissue contains a large number of stromal cells and is relatively easy to obtain in large quantities, and thus constitutes a very convenient stromal cell source. In this chapter, we introduce a rat periodontal tissue regeneration model using adipose-derived stem cells.

摘要

间充质干细胞能够有效地再生受损的牙周组织。由于牙周组织复杂，可分化为多种组织类型的间充质干细胞有助于牙周组织再生。事实上，在大鼠、犬、猪和猴等实验动物模型中，已经利用源自脂肪组织或骨髓的间充质干细胞进行了牙周组织再生研究。我们已经证明，脂肪来源的干细胞可以使大鼠牙周组织再生。脂肪组织含有大量基质细胞，相对容易大量获取，因此构成了一种非常便利的基质细胞来源。在本章中，我们介绍一种利用脂肪来源干细胞的大鼠牙周组织再生模型。