Department of Genetics and Molecular Biology, Pasteur Cenci-Bolognetti, Sapienza University, Rome, Italy.
Expert Rev Hematol. 2009 Aug;2(4):415-23. doi: 10.1586/ehm.09.32.
microRNAs (miRNAs) are short noncoding RNAs that function as post-transcriptional negative regulators of gene expression. They have been shown to be involved in the control of cell proliferation and differentiation, as well as acting as oncogenes or tumor-suppressor genes, suggesting their involvement in cancer development and progression. Expression profiles of human miRNAs have shown that many of them are aberrantly expressed in hematological malignancies. Therefore, miRNA profiling may be useful to distinguish between normal and tumor cells, and to create signatures for a variety of leukemia subtypes. Here, we review recent evidence for the involvement of miRNAs in the pathogenesis of different hematopoietic malignancies and their potential applications in diagnosis, prognosis and therapy of human leukemia.
microRNAs (miRNAs) 是短的非编码 RNA,作为基因表达的转录后负调控因子发挥作用。已经证明它们参与了细胞增殖和分化的控制,并且作为癌基因或肿瘤抑制基因发挥作用,这表明它们参与了癌症的发生和发展。人类 miRNA 的表达谱表明,许多 miRNA 在血液恶性肿瘤中异常表达。因此,miRNA 谱分析可能有助于区分正常细胞和肿瘤细胞,并为各种白血病亚型创建特征。在这里,我们综述了 miRNA 参与不同造血恶性肿瘤发病机制的最新证据,以及它们在人类白血病的诊断、预后和治疗中的潜在应用。