胰腺癌的化学预防：是否已准备好进入临床？
Chemoprevention of pancreatic cancer: ready for the clinic?
机构信息
Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA.
出版信息
Cancer Prev Res (Phila). 2010 Nov;3(11):1375-8. doi: 10.1158/1940-6207.CAPR-10-0216.
Abstract
Advances in our molecular, clinical, and epidemiologic understanding of the risk and development of pancreatic cancer offer hope for preventing this disease, which is largely intractable once developed. This perspective on provocative, genetically engineered mouse model work reported by Mohammed et al. (beginning on page 1417 in this issue of the journal) examines the prospects for pancreatic cancer chemoprevention with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI). Despite having limited value in advanced pancreatic cancer, EGFR TKIs show promise in the setting of early pancreatic carcinogenesis.
摘要
我们对胰腺癌风险和发展的分子、临床和流行病学认识的进展为预防这种疾病提供了希望，因为一旦发展，这种疾病在很大程度上是无法治愈的。Mohammed 等人（本期杂志第 1417 页开始）在具有挑战性的基因工程小鼠模型工作的这一观点，探讨了表皮生长因子受体（EGFR）酪氨酸激酶抑制剂（TKI）在胰腺癌化学预防中的前景。尽管在晚期胰腺癌中价值有限，但 EGFR TKI 在早期胰腺癌发生的情况下显示出希望。
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