Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
J Acquir Immune Defic Syndr. 2011 Jan 1;56(1):83-90. doi: 10.1097/QAI.0b013e3181fdc928.
Kaposi's sarcoma-associated herpesvirus (KSHV) seropositivity and lytic antibody titer are predictors for Kaposi's sarcoma.
We examined demographic, viral, and immunologic factors that influence KSHV latent and lytic antibodies in HIV-infected patients.
Detection rate of KSHV latent but not lytic antibodies was lower in patients with CD4 cells/mm3 less than 200 than greater than 200 (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.11-0.61) and CD8 cells/mm3 less than 400 than greater than 400 (OR, 0.26; 95% CI, 0.07-0.67). Overall seropositivity rate was higher in patients with CD4 cells/mm3 less than 200 than greater than 200 (OR, 2.34; 95% CI, 1.37-4.02) and HIV copies/mL greater than 400 than less than 400 (OR, 1.70; 95% CI, 1.09-2.65). Lytic antibody level was inversely correlated with CD4 count (P < 0.001). Lytic seropositivity (OR, 2.47; 95% CI, 1.35-4.50) and antibody level (adjusted difference mean optical density, 0.324; 95% CI, 0.16-0.46) were higher in patients with HIV infection greater than 15 than less than 15 years. Hispanics had higher lytic seropositivity rate (OR, 1.71; 95% CI, 1.07-2.73) and antibody level (adjusted difference mean optical density, 0.111; 95% CI, 0.03-0.18) than non-Hispanics.
Lower CD4 and CD8 counts impair antibody response to KSHV latent antigens. Immune deterioration, long-term HIV infection, and Hispanic status are risk factors for Kaposi's sarcoma predictors.
卡波西肉瘤相关疱疹病毒（KSHV）血清阳性和裂解抗体滴度是卡波西肉瘤的预测因子。
我们研究了影响 HIV 感染者 KSHV 潜伏和裂解抗体的人口统计学、病毒学和免疫学因素。
与 CD4 细胞/mm3 大于 200 的患者相比，CD4 细胞/mm3 小于 200 的患者潜伏抗体的检出率较低，而裂解抗体的检出率则无差异（比值比[OR]，0.26；95%置信区间[CI]，0.11-0.61）；与 CD8 细胞/mm3 大于 400 的患者相比，CD8 细胞/mm3 小于 400 的患者潜伏抗体的检出率较低，而裂解抗体的检出率则无差异（OR，0.26；95% CI，0.07-0.67）。与 CD4 细胞/mm3 大于 200 的患者相比，CD4 细胞/mm3 小于 200 的患者总血清阳性率较高（OR，2.34；95% CI，1.37-4.02），HIV 拷贝数/mL 大于 400 的患者比 HIV 拷贝数/mL 小于 400 的患者较高（OR，1.70；95% CI，1.09-2.65）。裂解抗体水平与 CD4 计数呈负相关（P < 0.001）。与 HIV 感染小于 15 年的患者相比，HIV 感染大于 15 年的患者的裂解血清阳性率（OR，2.47；95% CI，1.35-4.50）和抗体水平（调整后平均光密度差异，0.324；95% CI，0.16-0.46）较高。与非西班牙裔患者相比，西班牙裔患者的裂解血清阳性率（OR，1.71；95% CI，1.07-2.73）和抗体水平（调整后平均光密度差异，0.111；95% CI，0.03-0.18）较高。
较低的 CD4 和 CD8 计数会损害针对 KSHV 潜伏抗原的抗体反应。免疫恶化、长期 HIV 感染和西班牙裔身份是卡波西肉瘤预测因子的危险因素。
