双相情感障碍的基因研究数据库。
Database of genetic studies of bipolar disorder.
作者信息
Piletz John E, Zhang Xiaotong, Ranade Rajdeep, Liu Chunyu
机构信息
Department of Psychiatry, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA.
出版信息
Psychiatr Genet. 2011 Apr;21(2):57-68. doi: 10.1097/YPG.0b013e328341a346.
Abstract
This study describes the construction and preliminary analysis of a database of summary level genetic findings for bipolar disorder from the literature. The database is available for noncommercial use at http://bioprogramming.bsd.uchicago.edu/BDStudies/. This may be the first complete collection of published gene-specific linkage and association findings on bipolar disorder, including genome-wide association studies. Both the positive and negative findings have been incorporated so that the statistical and contextual significance of each finding may be compared semi-quantitatively and qualitatively across studies of mixed technologies. The database is appropriate for searching a literature populated by mainly underpowered studies, and if 'hits' are viewed as tentative knowledge for future hypothesis generation. It can serve as the basis for a mega-analysis of candidate genes. Herein, we discuss the most robust and best replicated gene findings to date in a contextual manner.
摘要
本研究描述了一个关于双相情感障碍文献中汇总水平基因研究结果数据库的构建及初步分析。该数据库可在http://bioprogramming.bsd.uchicago.edu/BDStudies/ 用于非商业用途。这可能是首个已发表的关于双相情感障碍的特定基因连锁和关联研究结果的完整集合，包括全基因组关联研究。阳性和阴性结果均已纳入，以便在混合技术研究中对每个结果的统计和背景意义进行半定量和定性比较。该数据库适用于在主要为低效能研究的文献中进行搜索，并且如果将“命中结果”视为未来假设生成的初步知识。它可作为候选基因元分析的基础。在此，我们以背景相关的方式讨论了迄今为止最可靠且得到最佳重复验证的基因研究结果。
相似文献
1
Database of genetic studies of bipolar disorder.双相情感障碍的基因研究数据库。
Psychiatr Genet. 2011 Apr;21(2):57-68. doi: 10.1097/YPG.0b013e328341a346.
2
Systematic review of genome-wide gene expression studies of bipolar disorder.双相情感障碍全基因组基因表达研究的系统评价。
BMC Psychiatry. 2013 Aug 15;13:213. doi: 10.1186/1471-244X-13-213.
3
Meta-analysis of genetic association studies on bipolar disorder.双相障碍遗传关联研究的荟萃分析。
Am J Med Genet B Neuropsychiatr Genet. 2012 Jul;159B(5):508-18. doi: 10.1002/ajmg.b.32057. Epub 2012 May 9.
4
A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex.人类前额叶皮质双相情感障碍全基因组表达谱的联合分析。
J Psychiatr Res. 2016 Nov;82:23-9. doi: 10.1016/j.jpsychires.2016.07.016. Epub 2016 Jul 18.
5
Association study of 83 candidate genes for bipolar disorder in chromosome 6q selected using an evidence-based prioritization algorithm.采用基于证据的优先级算法对 6q 染色体上的 83 个双相情感障碍候选基因进行关联研究。
Am J Med Genet B Neuropsychiatr Genet. 2013 Dec;162B(8):898-906. doi: 10.1002/ajmg.b.32200. Epub 2013 Sep 30.
6
Genome-wide association studies of bipolar disorder: A systematic review of recent findings and their clinical implications.双相情感障碍的全基因组关联研究：近期研究结果的系统综述及其临床意义。
Psychiatry Clin Neurosci. 2018 Feb;72(2):52-63. doi: 10.1111/pcn.12611. Epub 2017 Nov 13.
7
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.全基因组关联数据集的基因层面分析：精神分裂症和双相情感障碍存在多个常见风险等位基因及遗传风险重叠的证据。
Mol Psychiatry. 2009 Mar;14(3):252-60. doi: 10.1038/mp.2008.133. Epub 2008 Dec 9.
8
Genome-wide searches for bipolar disorder genes.全基因组搜索双相情感障碍基因。
Curr Psychiatry Rep. 2011 Dec;13(6):522-7. doi: 10.1007/s11920-011-0226-y.
9
A mega-analysis of genome-wide association studies for major depressive disorder.一项针对重度抑郁症的全基因组关联研究的 mega 分析。
Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3.
10
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.大规模全基因组关联分析发现双相情感障碍的新易感基因位点 ODZ4 附近。
Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943.
引用本文的文献
1
Characterization of Hemodynamic Alterations in Schizophrenia and Bipolar Disorder and Their Effect on Resting-State fMRI Functional Connectivity.精神分裂症和双相情感障碍的血液动力学改变及其对静息态 fMRI 功能连接的影响。
Schizophr Bull. 2022 May 7;48(3):695-711. doi: 10.1093/schbul/sbab140.
2
DNA Methylation as a Biomarker of Treatment Response Variability in Serious Mental Illnesses: A Systematic Review Focused on Bipolar Disorder, Schizophrenia, and Major Depressive Disorder.DNA 甲基化作为严重精神疾病治疗反应变异性的生物标志物：一项侧重于双相情感障碍、精神分裂症和重度抑郁症的系统评价。
Int J Mol Sci. 2018 Oct 4;19(10):3026. doi: 10.3390/ijms19103026.
3
Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders.弓形虫病与多基因疾病易感性基因：九种精神或神经疾病中广泛的弓形虫宿主/病原体相互作用组富集
J Pathog. 2013;2013:965046. doi: 10.1155/2013/965046. Epub 2013 Mar 4.
4
A comprehensive network and pathway analysis of candidate genes in major depressive disorder.重度抑郁症候选基因的综合网络和通路分析
BMC Syst Biol. 2011;5 Suppl 3(Suppl 3):S12. doi: 10.1186/1752-0509-5-S3-S12. Epub 2011 Dec 23.
5
ADHDgene: a genetic database for attention deficit hyperactivity disorder.ADHDgene：一个注意力缺陷多动障碍（ADHD）的基因数据库。
Nucleic Acids Res. 2012 Jan;40(Database issue):D1003-9. doi: 10.1093/nar/gkr992. Epub 2011 Nov 10.
6
Expression profiling in neuropsychiatric disorders: emphasis on glutamate receptors in bipolar disorder.神经精神疾病中的表达谱分析：重点关注双相情感障碍中的谷氨酸受体。
Pharmacol Biochem Behav. 2012 Feb;100(4):705-11. doi: 10.1016/j.pbb.2011.09.015. Epub 2011 Oct 8.
7
Brain expression quantitative trait locus mapping informs genetic studies of psychiatric diseases.脑表达数量性状基因座映射为精神疾病的遗传研究提供信息。
Neurosci Bull. 2011 Apr;27(2):123-33. doi: 10.1007/s12264-011-1203-5.
本文引用的文献
1
i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study.i-GSEA4GWAS：一个通过将改进的基因集富集分析应用于全基因组关联研究来识别与特征相关的途径/基因集的网络服务器。
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W90-5. doi: 10.1093/nar/gkq324. Epub 2010 Apr 30.
2
Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.对神经通路基因的全面拷贝数变异 (CNV) 分析在精神障碍患者中鉴定出了罕见的变异。
J Psychiatr Res. 2010 Oct;44(14):971-8. doi: 10.1016/j.jpsychires.2010.03.007. Epub 2010 Apr 15.
3
Genome-wide association study of bipolar I disorder in the Han Chinese population.汉族人群中双相情感障碍的全基因组关联研究。
Mol Psychiatry. 2011 May;16(5):548-56. doi: 10.1038/mp.2010.43. Epub 2010 Apr 13.
4
Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.ZNF804A 的精细定位及全基因组范围内的证据表明其与精神分裂症和双相情感障碍有关。
Mol Psychiatry. 2011 Apr;16(4):429-41. doi: 10.1038/mp.2010.36. Epub 2010 Apr 6.
5
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.双相情感障碍和重度抑郁症全基因组关联数据的荟萃分析。
Mol Psychiatry. 2011 Jan;16(1):2-4. doi: 10.1038/mp.2009.107. Epub 2010 Mar 30.
6
The P-value illusion: how to improve (psychiatric) genetic studies.P 值幻象：如何改进（精神科）遗传学研究。
Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):847-9. doi: 10.1002/ajmg.b.31076.
7
A novel analytical framework for dissecting the genetic architecture of behavioral symptoms in neuropsychiatric disorders.一种用于剖析神经精神障碍行为症状遗传结构的新分析框架。
PLoS One. 2010 Mar 16;5(3):e9714. doi: 10.1371/journal.pone.0009714.
8
Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.涉及神经元细胞黏附和膜支架的分子途径与精神分裂症和双相情感障碍的易感性有关。
Mol Psychiatry. 2011 Mar;16(3):286-92. doi: 10.1038/mp.2010.7. Epub 2010 Feb 16.
9
Beyond genome-wide association studies: genetic heterogeneity and individual predisposition to cancer.超越全基因组关联研究：癌症的遗传异质性和个体易感性。
Trends Genet. 2010 Mar;26(3):132-41. doi: 10.1016/j.tig.2009.12.008. Epub 2010 Jan 26.
10
The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions.基因-环境关联研究联盟（GENEVA）：通过跨多种疾病研究的合作，最大化从 GWAS 中获得的知识。
Genet Epidemiol. 2010 May;34(4):364-72. doi: 10.1002/gepi.20492.
Zotero 插件