3-(2-喹啉基)- 和 3,6-双(2-喹啉基)-9H-咔唑的合成。
Synthesis of 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles.
机构信息
Institute of Superfine Chemicals, Bohai University, Jinzhou 121000, China.
出版信息
Beilstein J Org Chem. 2010 Oct 8;6:966-72. doi: 10.3762/bjoc.6.108.
A simple and efficient synthesis of novel 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles, utilizing sodium ethoxide as a catalyst via a Friedländer condensation reaction between 3-acetyl-9-ethyl-9H-carbazole or 3,6-diacetyl-9-ethyl-9H-carbazole and β-aminoaldehydes or β-aminoketones is described. All of the title compounds were obtained in good yields of 52-72% and their structures were confirmed by IR, ¹H NMR, MS, and elemental analysis.
利用 3-乙酰基-9-乙基-9H-咔唑或 3,6-二乙酰基-9-乙基-9H-咔唑与β-氨基醛或β-氨基酮之间的 Friedländer 缩合反应，以乙醇钠作为催化剂，简便有效地合成了新型的 3-(喹啉-2-基)-和 3,6-双(喹啉-2-基)-9H-咔唑。所有标题化合物的产率均为 52-72%，通过 IR、1H NMR、MS 和元素分析确认了它们的结构。
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