Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Neuropathology. 2011 Aug;31(4):421-6. doi: 10.1111/j.1440-1789.2010.01166.x. Epub 2010 Nov 24.
Rhabdoid glioblastoma is a recently described entity in which a glioblastoma is associated with a rhabdoid component. Although rhabdoid glioblastoma has not appeared in the new World Health Organization classification of tumors of the CNS, it has a specific morphological feature and highly aggressive clinic process. Up to now, there have been six cases of rhabdoid glioblastoma reported in the literature. We report rhabdoid glioblastoma in the right front temporal lobe from a 31-year-old Chinese man. This tumor consisted of rhabdoid tumor cells with an eccentric nucleus and an eosinophilic cytoplasm. The tumor had an area appearing to be glioblastoma with microvascular proliferation and necrosis, and lacked a primitive neuroectodermal tumor component, and a mesenchymal component. Vimentin, epithelial membrane antigen, GFAP and integrase interactor (INI-1) expression were found in the tumor cells. Genetic abnormalities which include monosomy or a deletion of chromosome 22 were not found in this tumor. After 3 months post-surgery, the tumor was widespread in leptomeningia and the patient died. In conclusion, rhabdoid glioblastoma is a rare glioblastoma with poor prognosis; the differential diagnosis contained other rhabdoid tumors. This case will contribute to the profile of rhabdoid glioblastoma with typical morphology and immunophenotype, genetic and clinic features.
横纹肌样胶质母细胞瘤是一种新近描述的实体,其中胶质母细胞瘤与横纹肌样成分相关。尽管横纹肌样胶质母细胞瘤尚未出现在 CNS 肿瘤的新的世界卫生组织分类中,但它具有特定的形态学特征和高度侵袭性的临床过程。迄今为止,文献中已有 6 例横纹肌样胶质母细胞瘤的报道。我们报告了一例来自 31 岁中国男性的右额颞叶横纹肌样胶质母细胞瘤。该肿瘤由具有偏心核和嗜酸性细胞质的横纹肌样肿瘤细胞组成。肿瘤的一部分表现为具有微血管增生和坏死的胶质母细胞瘤,缺乏原始神经外胚层肿瘤成分和间充质成分。肿瘤细胞表达波形蛋白、上皮膜抗原、GFAP 和整合酶相互作用蛋白(INI-1)。该肿瘤未发现染色体 22 单体型缺失或缺失等遗传异常。手术后 3 个月,肿瘤广泛播散至软脑膜,患者死亡。总之,横纹肌样胶质母细胞瘤是一种罕见的预后不良的胶质母细胞瘤;鉴别诊断包括其他横纹肌样肿瘤。该病例将有助于了解具有典型形态学和免疫表型、遗传学和临床特征的横纹肌样胶质母细胞瘤的特征。