Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA.
Steroids. 2011 Jan;76(1-2):1-10. doi: 10.1016/j.steroids.2010.11.003. Epub 2010 Nov 18.
MicroRNAs (miRNAs) are small non-coding RNAs that serve as post-transcriptional regulators of gene expression. They work predominantly by binding to complementary sequences in target messenger RNA (mRNA) 3' untranslated regions (UTRs) where they prevent translation or cause degradation of the message. Steroid hormone receptors (SHRs) are ligand-activated transcription factors that regulate genes in steroid responsive tissues. Recent studies demonstrate that SHRs regulate miRNAs, and in turn, miRNAs can regulate SHR expression and function. Mounting evidence indicates that miRNAs are intimately involved with SHRs, as they are with other transcription factors, often in double negative feedback loops. Investigators are just beginning to expose the details of these complex relationships and reveal the extent to which miRNAs are involved with SHRs in normal physiology and the pathobiology of steroid hormone responsive tissues.
微小 RNA（miRNAs）是一类小的非编码 RNA，作为基因表达的转录后调控因子。它们主要通过与靶信使 RNA（mRNA）3'非翻译区（UTR）中的互补序列结合来发挥作用，在那里它们阻止翻译或导致 mRNA 的降解。甾体激素受体（SHRs）是配体激活的转录因子，可调节甾体激素反应组织中的基因。最近的研究表明，SHRs 可以调节 miRNAs，反过来，miRNAs 也可以调节 SHR 的表达和功能。越来越多的证据表明，miRNAs 与 SHR 密切相关，就像它们与其他转录因子一样，通常在双重负反馈回路中。研究人员才刚刚开始揭示这些复杂关系的细节，并揭示 miRNAs 在甾体激素反应组织的正常生理学和病理生物学中与 SHRs 相关的程度。
