Department of Infection Prevention, WakeMed Health & Hospitals, 3000 New Bern Ave., Raleigh, NC 27610, USA.
Am J Infect Control. 2010 Dec;38(10):817-21. doi: 10.1016/j.ajic.2010.06.005.
Central line-associated bloodstream infections (CLABSI) contribute to increased morbidity, mortality, length of stay, and excessive cost of care.
This study was an observational cohort study using historical controls in the setting of a 9-bed surgical intensive care unit in a Level I trauma center; all patients admitted or transferred into the unit were enrolled in the study.
A quality improvement intervention protocol was instituted to reduce CLABSI incidence with a 3-month effectiveness study using 2% chlorhexidine gluconate-impregnated cloths for daily patient bathing; education of surgical intensive care unit staff on changes to CLABSI prevention protocol and all existing CLABSI prevention policies and bundles already in place; and compliance monitoring and documentation.
The 3-month effectiveness study showed a decrease in CLABSI rates from 12.07 CLABSIs per 1000 central line-days to 3.17 CLABSIs per 1000 central line-days (73.7% rate reduction; P = .0358).
CLABSI incidence rates were reduced in a high-risk patient population using evidence-based prevention bundles and implementing daily bathing with 2% chlorhexidine gluconate nonrinse cloths.
中心静脉相关血流感染（CLABSI）会导致发病率、死亡率、住院时间和医疗费用增加。
这是一项观察性队列研究，在一级创伤中心的 9 张外科重症监护病房中使用历史对照，所有入住或转入该病房的患者均纳入研究。
采用 2%葡萄糖酸洗必泰浸渍布进行每日患者沐浴的质量改进干预方案，以降低 CLABSI 发生率，该方案进行了为期 3 个月的有效性研究；对外科重症监护病房工作人员进行 CLABSI 预防方案和所有现有 CLABSI 预防政策和套件变化的教育，并加强合规性监测和记录。
3 个月的有效性研究显示，CLABSI 发生率从每千中心静脉导管日 12.07 例下降至每千中心静脉导管日 3.17 例（降低 73.7%；P =.0358）。
在高危患者人群中，使用基于证据的预防套件和实施每日用 2%葡萄糖酸洗必泰免冲洗布沐浴可降低 CLABSI 发生率。
