干细胞因子、白细胞介素-16和白细胞介素-2受体α是移植功能延迟和缓慢的预测生物标志物。
Stem cell factor, interleukin-16, and interleukin-2 receptor alpha are predictive biomarkers for delayed and slow graft function.
作者信息
Alachkar N, Ugarte R, Huang E, Womer K L, Montgomery R, Kraus E, Rabb H
机构信息
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
Transplant Proc. 2010 Nov;42(9):3399-405. doi: 10.1016/j.transproceed.2010.06.013.
INTRODUCTION
Delayed graft function (DGF) and slow graft function (SGF) due to ischemic and reperfusion injury (IRI) are common complications of deceased donor kidney transplantation. We tested whether a panel of serum and urine cytokines represent early biomarkers for DGF and SGF.
METHODS
We collected serum and urine samples from 61 patients 48 hours posttransplantation and used a multiplex enzyme-linked immunosorbent assay (ELISA) technique to measure levels of 23 cytokines. Fourteen patients developed poor graft function (PGF), with 6 having DGF and 8 with SGF.
RESULTS
Area under receiver operation characteristics curve (AUC) demonstrated the following: serum levels of SCF (0.88) and interleukin (IL) 16 (0.74).
CONCLUSIONS
This study showed that a select panel of cytokines measured early post kidney transplantation may predict poor graft function.
引言
由于缺血再灌注损伤（IRI）导致的移植肾功能延迟恢复（DGF）和移植肾功能缓慢恢复（SGF）是尸体供肾移植常见的并发症。我们测试了一组血清和尿液细胞因子是否可作为DGF和SGF的早期生物标志物。
方法
我们在移植后48小时收集了61例患者的血清和尿液样本，并使用多重酶联免疫吸附测定（ELISA）技术来测量23种细胞因子的水平。14例患者移植肾功能不佳（PGF），其中6例发生DGF，8例发生SGF。
结果
受试者操作特征曲线下面积（AUC）显示如下：血清干细胞因子（SCF）水平为0.88，白细胞介素（IL）-16水平为0.74。
结论
本研究表明，肾移植后早期检测的一组特定细胞因子可能预测移植肾功能不佳。
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