Hayes D, Zwischenberger J B, Mansour H M
Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA.
Transplant Proc. 2010 Nov;42(9):3876-9. doi: 10.1016/j.transproceed.2010.08.029.
Long-term outcomes after lung transplantation remain poor mainly to the development of bronchiolitis obliterans syndrome (BOS). Currently, treatment options for BOS are very limited. Strategies to prevent and treat this complication include the use of aerosolized therapy with only cyclosporine used in patients to date. We describe the use of aerosolized tacrolimus in a lung transplant recipient with BOS. The patient demonstrated clinical improvement in functional capacity and oxygenation while receiving tacrolimus by nebulization. Further research is needed to study whether aerosolized tacrolimus is beneficial in lung transplant recipients with BOS.
肺移植后的长期预后仍然很差，主要是因为闭塞性细支气管炎综合征（BOS）的发展。目前，BOS的治疗选择非常有限。预防和治疗这种并发症的策略包括使用雾化疗法，迄今为止仅在患者中使用环孢素。我们描述了雾化他克莫司在一名患有BOS的肺移植受者中的应用。该患者在通过雾化接受他克莫司治疗时，功能能力和氧合情况有了临床改善。需要进一步研究雾化他克莫司对患有BOS的肺移植受者是否有益。
