压力与过敏性疾病。
Stress and allergic diseases.
机构信息
Laboratory of Behavioral Immunology Research, Division of Clinical Immunology and Allergy, Department of Medicine, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA.
出版信息
Immunol Allergy Clin North Am. 2011 Feb;31(1):55-68. doi: 10.1016/j.iac.2010.09.009.
Allergy describes a constellation of clinical diseases that affect up to 30% of the world's population. It is characterized by production of allergen-specific IgE, which binds to mast cells and initiates a cascade of molecular and cellular events that affect the respiratory tract (rhinitis and asthma), skin (dermatitis, urticaria), and multiple systems (anaphylaxis) in response to a variety of allergens including pollens, mold spores, animal danders, insect stings, foods, and drugs. The underlying pathophysiology involves immunoregulatory dysfunctions similar to those noted in highly stressed populations. The relationships in terms of potential for intervention are discussed.
过敏反应描述了一系列影响全球多达 30%人口的临床疾病。其特征是产生过敏原特异性 IgE，该 IgE 与肥大细胞结合，并引发一系列分子和细胞事件，从而导致呼吸道（鼻炎和哮喘）、皮肤（皮炎、荨麻疹）和多个系统（过敏反应）对各种过敏原（包括花粉、霉菌孢子、动物皮屑、昆虫蜇伤、食物和药物）产生反应。潜在的病理生理学涉及到类似于在高度紧张人群中观察到的免疫调节功能障碍。讨论了潜在干预的相关性。
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