血管生成在神经内分泌肿瘤中的作用。

The role of angiogenesis in neuroendocrine tumors.

机构信息

Department of Surgery, Louisiana State University, Health Sciences Center, New Orleans, LA 70112, USA.

出版信息

Endocrinol Metab Clin North Am. 2010 Dec;39(4):839-52. doi: 10.1016/j.ecl.2010.08.006.

DOI:10.1016/j.ecl.2010.08.006

Abstract

The first studies to assess in vitro angiogenesis in neuroendocrine tumors used animal-based assays to study the antiangiogenic properties of somatostatin analogs. Current technologies enable investigators to directly appraise the in vitro angiogenic response of an individual's neuroendocrine tumor with and without potential antiangiogenic reagents. This article describes the evolution of methods to assess in vitro angiogenesis in neuroendocrine tumors and describes some of the clinical data.

摘要

最早研究神经内分泌肿瘤体外血管生成的方法是基于动物的实验，用于研究生长抑素类似物的抗血管生成特性。当前的技术使研究人员能够直接评估个体神经内分泌肿瘤在有无潜在抗血管生成试剂存在时的体外血管生成反应。本文描述了评估神经内分泌肿瘤体外血管生成的方法的演变，并描述了一些临床数据。