Saito Itsuro, Ishii Kohei, Isoyama Takashi, Ono Toshiya, Nakagawa Hidemoto, Shi Wei, Inoue Yusuke, Abe Yusuke
Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Japan.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:5218-21. doi: 10.1109/IEMBS.2010.5626283.
The undulation pump ventricular assist device (UPVAD) is a small implantable ventricular assist device using an undulation pump. The UPVAD can produce pulsatile flow by changing the motor rotation speed of the UPVAD. Because the undulation pump is a volume displacement type pump, the inflow sucking occurs easily. The purpose of this study is to develop a suitable control method for the UPVAD. The UPVAD inflow cannula equipped with an implantable pressure sensor was inserted into the ventricle. Therefore, pressure variation that synchronized with the natural heartbeat and negative pressure spike caused the inflow sucking were observed. By changing the motor rotation speed that responded to the inflow pressure, the UPVAD could synchronize with the natural heartbeat and the UPVAD could generate a co-pulse assist flow. The inflow sucking could be released by reducing the motor rotation speed, if the inflow sucking was detected. The newly developed control method exhibited superior characteristics than existing ones due to high immunity against pressure sensor drift. The assist flow could be increased more than 15% and the inflow sucking occurrence could be decreased with this control method. The UPVAD could generate the suitable assist flow with the developed control method.
波动泵心室辅助装置（UPVAD）是一种使用波动泵的小型可植入式心室辅助装置。UPVAD可通过改变其电机转速来产生搏动性血流。由于波动泵是容积置换型泵，所以容易发生流入抽吸。本研究的目的是为UPVAD开发一种合适的控制方法。将配备有可植入压力传感器的UPVAD流入插管插入心室。因此，观察到与自然心跳同步的压力变化以及导致流入抽吸的负压尖峰。通过改变响应流入压力的电机转速，UPVAD可与自然心跳同步，并且UPVAD可产生协同搏动辅助血流。如果检测到流入抽吸，可通过降低电机转速来解除流入抽吸。新开发的控制方法由于对压力传感器漂移具有高抗干扰性，因此表现出优于现有方法的特性。使用这种控制方法，辅助血流可增加超过15%，并且流入抽吸的发生率可降低。UPVAD可通过所开发的控制方法产生合适的辅助血流。
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