Ferrario Manuela, Moissl Ulrich, Garzotto Francesco, Signorini Maria G, Cruz Dinna, Tetta Ciro, Ronco Claudio, Gatti Emanuele, Cerutti Sergio
Politecnico di Milano, Department of Bioengineering, P.zza Leonardo da Vinci 32, 20133, Italy.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:3796-9. doi: 10.1109/IEMBS.2010.5627559.
This work aims at studying the autonomic nervous system (ANS) response to hemodialysis (HD) treatment in a population of end stage renal disease (ESRD) patients. ECG Holter recordings and whole body bioimpedance spectroscopy measurements were performed for each patient. Patients were classified according to the fluid overload (FO) values and the systolic blood pressure (SBP) measured before HD. Time domain and frequency domain indices from heart rate variability (HRV) signals were measured for the first 30 minutes and last 30 minutes of HD, the first hour after HD, and night (12.00 p.m.-4 a.m.). Significant differences were obtained in fluid overloaded but normotensive patients (Group IV) with respect to fluid overloaded and hypertensive patients (Group I) and normohydrated and normotensive patients (Group N+Dx). In particular, SDNN, RMSSD, SDSD, pNN50%, indices resulted significantly higher in Group IV with respect to the other groups. Overhydrated patients with hypertension (Group I) showed a blunted parasympathetic activity, which is supposed to contribute to hypertension.
这项工作旨在研究终末期肾病（ESRD）患者群体中自主神经系统（ANS）对血液透析（HD）治疗的反应。对每位患者进行了心电图动态记录和全身生物电阻抗光谱测量。根据血液透析前测量的液体超负荷（FO）值和收缩压（SBP）对患者进行分类。在血液透析的前30分钟和最后30分钟、血液透析后的第一小时以及夜间（晚上12点至凌晨4点）测量心率变异性（HRV）信号的时域和频域指标。在液体超负荷但血压正常的患者（IV组）与液体超负荷且高血压的患者（I组）以及液体正常且血压正常的患者（N+Dx组）之间获得了显著差异。特别是，IV组的SDNN、RMSSD、SDSD、pNN50%指标相对于其他组显著更高。高血压的液体过多患者（I组）表现出副交感神经活动减弱，这被认为是导致高血压的原因之一。
