甲氨蝶呤及甲氨蝶呤加亚叶酸对白血病细胞（L1210）的清除作用 - Suppr

Eradication of leukaemic cells (L1210) by methotrexate and methotrexate plus citrovorum factor.

作者信息

Goldin A, Venditti J M, Kline I, Mantel N

机构信息

Drug Evaluation Branch and Biometry Branch, National Cancer Institute and Microbiological Associates, Bethesda, Maryland, USA.

出版信息

Nature. 1966 Dec 31;212(5070):1548-50. doi: 10.1038/2121548a0.

DOI:10.1038/2121548a0

PMID:21105503

Abstract

摘要

相似文献

Eradication of leukaemic cells (L1210) by methotrexate and methotrexate plus citrovorum factor.

Nature. 1966 Dec 31;212(5070):1548-50. doi: 10.1038/2121548a0.

High-dose methotrexate therapy with citrovorum factor: a pharmacologic perspective in murine tumor models.

Cancer Treat Rep. 1977 Jul;61(4):565-74.

Biochemical and pharmacokinetic effects of leucovorin after high-dose methotrexate in a murine leukemia model.

Cancer Res. 1976 Dec;36(12):4679-86.

Limited effectiveness of in vitro high-dose methotrexate and leucovorin to overcome resistance in L1210 leukemia cells with elevations of dihydrofolate reductase.

Eur J Cancer (1965). 1980 Aug;16(8):1057-63. doi: 10.1016/0014-2964(80)90253-4.

Bullous variant of acral erythema in a child after high-dose methotrexate.

Pediatr Hematol Oncol. 2012 May;29(4):378-9. doi: 10.3109/08880018.2012.665982.

Investigations on the mechanisms of methotrexate resistance in a cisplatin-resistant L1210 murine leukemia cell subline.

Cancer Chemother Pharmacol. 1996;37(4):337-42. doi: 10.1007/s002800050394.

Gemcitabine-induced apoptosis in a drug-resistant mouse leukemia L1210 cell line that does not express p53.

Adv Enzyme Regul. 2004;44:11-25. doi: 10.1016/j.advenzreg.2003.11.011.

Problems with nomenclature and pharmacodynamics in trophoblastic disease.

J Clin Oncol. 2004 Jan 1;22(1):203-4; author reply 204. doi: 10.1200/JCO.2004.99.161.

Modulation of methotrexate resistance by genistein in murine leukemia L1210 cells.

Oncol Rep. 1998 Mar-Apr;5(2):419-21.

Methotrexate and leucovorin double-modulated 5-fluorouracil combined with cisplatin (MPFL) in metastatic/recurrent head and neck cancer.

J Chin Med Assoc. 2008 Jul;71(7):336-41. doi: 10.1016/S1726-4901(08)70135-7.

引用本文的文献

The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia.

BMC Cancer. 2020 Sep 30;20(1):940. doi: 10.1186/s12885-020-07422-y.

Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia.

PLoS One. 2020 May 18;15(5):e0231588. doi: 10.1371/journal.pone.0231588. eCollection 2020.

The utility of online haemodiafiltration in methotrexate poisoning.

BMJ Case Rep. 2014 May 23;2014:bcr2014203530. doi: 10.1136/bcr-2014-203530.

The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro.

Cancer Chemother Pharmacol. 2014 May;73(5):1055-62. doi: 10.1007/s00280-014-2441-9. Epub 2014 Mar 29.

Quantitative aspects of the selective killing of transformed cells by methotrexate in the presence of leucovorin.

In Vitro Cell Dev Biol Anim. 1999 Jul-Aug;35(7):394-402. doi: 10.1007/s11626-999-0114-5.

Selective killing of preneoplastic and neoplastic cells by methotrexate with leucovorin.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4550-5. doi: 10.1073/pnas.95.8.4550.

Reduction in the toxicity of aminopterin--monoclonal-antibody conjugates by leucovorin.

Cancer Immunol Immunother. 1994 Aug;39(2):135-9. doi: 10.1007/BF01525319.

Microcinematographic study on the effect of methotrexate upon mouse mammary tumor cells (MMT cell line).

Cancer Chemother Pharmacol. 1980;4(1):53-60. doi: 10.1007/BF00255460.

[Dihydrofolate reductase and thymidine kinase in the bone marrow under the influence of folic acid antagonists].

Klin Wochenschr. 1967 Oct 1;45(19):987-94. doi: 10.1007/BF01746131.

Comparison of leucovorin protection from variety of antifolates in human lymphoid cell lines.

Cancer Chemother Pharmacol. 1985;15(2):111-4. doi: 10.1007/BF00257519.

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Eradication of leukaemic cells (L1210) by methotrexate and methotrexate plus citrovorum factor.

作者信息

Goldin A, Venditti J M, Kline I, Mantel N

机构信息

Drug Evaluation Branch and Biometry Branch, National Cancer Institute and Microbiological Associates, Bethesda, Maryland, USA.

出版信息

Nature. 1966 Dec 31;212(5070):1548-50. doi: 10.1038/2121548a0.

DOI:10.1038/2121548a0

PMID:21105503

Abstract

摘要

相似文献

Eradication of leukaemic cells (L1210) by methotrexate and methotrexate plus citrovorum factor.

Nature. 1966 Dec 31;212(5070):1548-50. doi: 10.1038/2121548a0.

High-dose methotrexate therapy with citrovorum factor: a pharmacologic perspective in murine tumor models.

Cancer Treat Rep. 1977 Jul;61(4):565-74.

Biochemical and pharmacokinetic effects of leucovorin after high-dose methotrexate in a murine leukemia model.

Cancer Res. 1976 Dec;36(12):4679-86.

Limited effectiveness of in vitro high-dose methotrexate and leucovorin to overcome resistance in L1210 leukemia cells with elevations of dihydrofolate reductase.

Eur J Cancer (1965). 1980 Aug;16(8):1057-63. doi: 10.1016/0014-2964(80)90253-4.

Bullous variant of acral erythema in a child after high-dose methotrexate.

Pediatr Hematol Oncol. 2012 May;29(4):378-9. doi: 10.3109/08880018.2012.665982.

Investigations on the mechanisms of methotrexate resistance in a cisplatin-resistant L1210 murine leukemia cell subline.

Cancer Chemother Pharmacol. 1996;37(4):337-42. doi: 10.1007/s002800050394.

Gemcitabine-induced apoptosis in a drug-resistant mouse leukemia L1210 cell line that does not express p53.

Adv Enzyme Regul. 2004;44:11-25. doi: 10.1016/j.advenzreg.2003.11.011.

Problems with nomenclature and pharmacodynamics in trophoblastic disease.

J Clin Oncol. 2004 Jan 1;22(1):203-4; author reply 204. doi: 10.1200/JCO.2004.99.161.

Modulation of methotrexate resistance by genistein in murine leukemia L1210 cells.

Oncol Rep. 1998 Mar-Apr;5(2):419-21.

Methotrexate and leucovorin double-modulated 5-fluorouracil combined with cisplatin (MPFL) in metastatic/recurrent head and neck cancer.

J Chin Med Assoc. 2008 Jul;71(7):336-41. doi: 10.1016/S1726-4901(08)70135-7.

引用本文的文献

The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia.

BMC Cancer. 2020 Sep 30;20(1):940. doi: 10.1186/s12885-020-07422-y.

Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia.

PLoS One. 2020 May 18;15(5):e0231588. doi: 10.1371/journal.pone.0231588. eCollection 2020.

The utility of online haemodiafiltration in methotrexate poisoning.

BMJ Case Rep. 2014 May 23;2014:bcr2014203530. doi: 10.1136/bcr-2014-203530.

The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro.

Cancer Chemother Pharmacol. 2014 May;73(5):1055-62. doi: 10.1007/s00280-014-2441-9. Epub 2014 Mar 29.

Quantitative aspects of the selective killing of transformed cells by methotrexate in the presence of leucovorin.

In Vitro Cell Dev Biol Anim. 1999 Jul-Aug;35(7):394-402. doi: 10.1007/s11626-999-0114-5.

Selective killing of preneoplastic and neoplastic cells by methotrexate with leucovorin.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4550-5. doi: 10.1073/pnas.95.8.4550.

Reduction in the toxicity of aminopterin--monoclonal-antibody conjugates by leucovorin.

Cancer Immunol Immunother. 1994 Aug;39(2):135-9. doi: 10.1007/BF01525319.

Microcinematographic study on the effect of methotrexate upon mouse mammary tumor cells (MMT cell line).

Cancer Chemother Pharmacol. 1980;4(1):53-60. doi: 10.1007/BF00255460.

[Dihydrofolate reductase and thymidine kinase in the bone marrow under the influence of folic acid antagonists].

Klin Wochenschr. 1967 Oct 1;45(19):987-94. doi: 10.1007/BF01746131.

Comparison of leucovorin protection from variety of antifolates in human lymphoid cell lines.

Cancer Chemother Pharmacol. 1985;15(2):111-4. doi: 10.1007/BF00257519.

Eradication of leukaemic cells (L1210) by methotrexate and methotrexate plus citrovorum factor.

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Eradication of leukaemic cells (L1210) by methotrexate and methotrexate plus citrovorum factor.

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