Department of Histopathology, Salford Royal NHS Foundation Trust, Salford, UK.
J Clin Pathol. 2011 Feb;64(2):110-3. doi: 10.1136/jcp.2010.075945. Epub 2010 Nov 23.
Barrett oesophagus (BO) occurs as a consequence of prolonged gastro-oesophageal reflux and it may precede the development of oesophageal adenocarcinoma.
The aim of this study was to accurately assess Cdx2 expression in the oesophageal metaplasia-dysplasia-adenocarcinoma sequence.
The expression of the transcription factor Cdx2 in Barrett metaplasia, high-grade glandular dysplasia and adenocarcinoma was investigated using immunohistochemistry.
The results confirmed previous immunohistochemistry and PCR-based investigations, indicating that Cdx2 was expressed by intestinal metaplasia in the oesophagus. In addition, upregulation followed by linear downregulation of Cdx2 expression through the oesophageal metaplasia-dysplasia-adenocarcinoma sequence was demonstrated for the first time.
Such downregulation of Cdx2 expression could be in keeping with a role as a tumour suppressor gene, but a simpler explanation would be downregulation of a differentiation marker.
巴雷特食管（BO）是由于长期胃食管反流引起的，它可能先于食管腺癌的发展。
本研究的目的是准确评估 Cdx2 在食管化生-异型增生-腺癌序列中的表达。
采用免疫组织化学方法检测转录因子 Cdx2 在 Barrett 化生、高级别腺上皮异型增生和腺癌中的表达。
结果证实了先前的免疫组织化学和基于 PCR 的研究，表明 Cdx2 被肠道化生表达在食管中。此外，首次通过食管化生-异型增生-腺癌序列证明 Cdx2 表达的上调，然后是线性下调。
Cdx2 表达的这种下调可能与肿瘤抑制基因的作用有关，但更简单的解释可能是分化标志物的下调。
