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巨脑回畸形:2D、3D 超声与 MRI 的相关性。

Hemimegalencephaly: 2D, 3D Ultrasound and MRI Correlation.

机构信息

Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.

出版信息

Fetal Diagn Ther. 2011;29(3):257-60. doi: 10.1159/000322012. Epub 2010 Nov 27.

Abstract

BACKGROUND

Hemimegalencephaly (HMC) is a disorder associated with enlarged and dysplastic hamartomatous overgrowth of all or part of the one cerebral hemisphere that can be isolated or associated with other syndromes. In the normal development of the brain it is important to bear in mind that there are two main processes: firstly the development of the hemispheres and the corpus callosum, and secondly the cortical formation with proliferation, migration and organization of the cortex, which occurs mostly between 12 and 20 weeks of gestation.

CASE REPORT

We present a 22-week-old fetus with macrocephaly depending on HMC and emphasize the possibility of an early ultrasound diagnosis, the correlation in the diagnosis between 2D and 3D ultrasound, and the use of magnetic resonance imaging as an imaging method for a more precise diagnosis of neuronal migration anomalies.

CONCLUSION

The diagnosis of HMC is possible at the time of the anomaly scan. The use and correlation with other diagnostic tools provide essential information for parent counseling in these complex cases.

摘要

背景

巨脑回畸形(HMC)是一种与单侧大脑半球全部或部分过度生长的肥大和发育不良有关的疾病,可孤立存在或与其他综合征相关。在大脑的正常发育过程中,需要牢记两个主要过程:首先是大脑半球和胼胝体的发育,其次是皮质形成,包括皮质的增殖、迁移和组织,这主要发生在妊娠 12 至 20 周之间。

病例报告

我们介绍了一名 22 周大的胎儿,患有巨脑回畸形,主要依赖于 HMC,并强调了早期超声诊断的可能性,二维和三维超声诊断之间的相关性,以及磁共振成像作为一种更精确诊断神经元迁移异常的成像方法的应用。

结论

在异常扫描时可以诊断出 HMC。使用和与其他诊断工具的相关性为这些复杂病例的家长咨询提供了重要信息。

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