Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Acta Pharmacol Sin. 2010 Dec;31(12):1523-31. doi: 10.1038/aps.2010.186.
More and more attention in the field of drug discovery has been focused on the neuroprotection of natural compounds from traditional medicinal herbs. Cerebral ischemia is a complex pathological process involving a series of mechanisms, and a framework for the development of neuroprotectants from traditional herb medicine is a promising treatment for cerebral ischemia. Natural compounds with the effects of anti-oxidation, anti-inflammation, calcium antagonization, anti-apoptosis, and neurofunctional regulation exhibit preventive or therapeutic effects on experimental ischemic brain injury. According to the pharmacological mechanisms underlying neuroprotection, we evaluated natural products from traditional medicinal herbs that exhibit protective effects on ischemic brain injury and characterized the promising targets.
越来越多的药物发现领域的研究人员开始关注从传统草药中寻找具有神经保护作用的天然化合物。脑缺血是一个涉及一系列机制的复杂病理过程,从传统草药中开发神经保护剂的框架为脑缺血的治疗提供了一个很有前途的方法。具有抗氧化、抗炎、钙拮抗、抗细胞凋亡和神经功能调节作用的天然化合物对实验性缺血性脑损伤具有预防或治疗作用。根据神经保护的药理机制,我们评估了具有缺血性脑损伤保护作用的传统草药中的天然产物,并对有希望的作用靶点进行了特征描述。