胆碱能系统和新纹状体的记忆功能。
The cholinergic system and neostriatal memory functions.
机构信息
Department of Biology, University of Pennsylvania, 433 S University Avenue, Philadelphia, PA 19104, USA.
出版信息
Behav Brain Res. 2011 Aug 10;221(2):412-23. doi: 10.1016/j.bbr.2010.11.047. Epub 2010 Dec 1.
Abstract
The striatum is one of the major forebrain regions that strongly expresses muscarinic and nicotinic cholinergic receptors. This article reviews the current knowledge and our new findings about the striatal cholinoceptive organization and its role in a variety of cognitive functions. Pharmacological and genetic manipulations have indicated that the cholinergic and dopaminergic system in the striatum modulate each other's function. In addition to modulating the dopaminergic system, nicotinic cholinergic receptors facilitate GABA release, whereas muscarinic receptors attenuate GABA release. The striatal cholinergic system has also been implicated in various cognitive functions including procedural learning and intradimensional set shifting. Together, these data indicate that the cholinergic system in the striatum is involved in a diverse set of cognitive functions through interactions with other neurotransmitter systems including the dopaminergic and GABAergic systems.
摘要
纹状体是前脑的主要区域之一，强烈表达毒蕈碱和烟碱型乙酰胆碱受体。本文综述了关于纹状体胆碱能感受组织及其在各种认知功能中的作用的现有知识和我们的新发现。药理学和遗传学操作表明，纹状体中的胆碱能和多巴胺能系统相互调节彼此的功能。除了调节多巴胺能系统外，烟碱型乙酰胆碱受体还促进 GABA 的释放，而毒蕈碱型受体则减弱 GABA 的释放。纹状体胆碱能系统还与各种认知功能有关，包括程序性学习和维度内转换。综上所述，这些数据表明，纹状体中的胆碱能系统通过与包括多巴胺能和 GABA 能系统在内的其他神经递质系统相互作用，参与了一系列不同的认知功能。
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本文引用的文献
1
Studies in spatial learning; place learning versus response learning.空间学习研究；位置学习与反应学习
J Exp Psychol. 1946 Jun;36:221-9. doi: 10.1037/h0060262.
2
Studies in spatial learning; response learning vs. place learning by the non-correction method.
J Exp Psychol. 1947 Aug;37(4):285-92. doi: 10.1037/h0057434.
3
Sleep deprivation impairs spatial working memory and reduces hippocampal AMPA receptor phosphorylation.睡眠剥夺会损害空间工作记忆并减少海马 AMPA 受体磷酸化。
J Sleep Res. 2010 Jun;19(2):280-8. doi: 10.1111/j.1365-2869.2009.00799.x. Epub 2009 Dec 28.
4
Drastic decrease in dopamine receptor levels in the striatum of acetylcholinesterase knock-out mouse.纹状体中乙酰胆碱酯酶敲除小鼠多巴胺受体水平的急剧下降。
Chem Biol Interact. 2010 Jan 5;183(1):194-201. doi: 10.1016/j.cbi.2009.09.025.
5
Excitatory roles of protein kinase C in striatal cholinergic interneurons.蛋白激酶 C 在纹状体胆碱能中间神经元中的兴奋作用。
J Neurophysiol. 2009 Oct;102(4):2453-61. doi: 10.1152/jn.00325.2009. Epub 2009 Aug 5.
6
Anxiety, cognition, and habit: a multiple memory systems perspective.焦虑、认知与习惯：多重记忆系统视角
Brain Res. 2009 Oct 13;1293:121-8. doi: 10.1016/j.brainres.2009.03.029. Epub 2009 Mar 27.
7
Striatal plasticity and basal ganglia circuit function.纹状体可塑性与基底神经节回路功能。
Neuron. 2008 Nov 26;60(4):543-54. doi: 10.1016/j.neuron.2008.11.005.
8
Nicotinic and muscarinic cholinergic receptors coexist on GABAergic nerve endings in the mouse striatum and interact in modulating GABA release.
Neuropharmacology. 2009 Mar;56(3):610-4. doi: 10.1016/j.neuropharm.2008.10.014. Epub 2008 Nov 8.
9
A double dissociation revealing bidirectional competition between striatum and hippocampus during learning.一项双分离研究揭示了学习过程中纹状体与海马体之间的双向竞争。
Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17163-8. doi: 10.1073/pnas.0807749105. Epub 2008 Oct 27.
10
Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex.猴子内侧纹状体的损伤在反转学习过程中会产生持续性损伤，类似于眶额叶皮质损伤所产生的损伤。
J Neurosci. 2008 Oct 22;28(43):10972-82. doi: 10.1523/JNEUROSCI.1521-08.2008.
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