胆碱能系统和新纹状体的记忆功能。
The cholinergic system and neostriatal memory functions.
机构信息
Department of Biology, University of Pennsylvania, 433 S University Avenue, Philadelphia, PA 19104, USA.
出版信息
Behav Brain Res. 2011 Aug 10;221(2):412-23. doi: 10.1016/j.bbr.2010.11.047. Epub 2010 Dec 1.
Abstract
The striatum is one of the major forebrain regions that strongly expresses muscarinic and nicotinic cholinergic receptors. This article reviews the current knowledge and our new findings about the striatal cholinoceptive organization and its role in a variety of cognitive functions. Pharmacological and genetic manipulations have indicated that the cholinergic and dopaminergic system in the striatum modulate each other's function. In addition to modulating the dopaminergic system, nicotinic cholinergic receptors facilitate GABA release, whereas muscarinic receptors attenuate GABA release. The striatal cholinergic system has also been implicated in various cognitive functions including procedural learning and intradimensional set shifting. Together, these data indicate that the cholinergic system in the striatum is involved in a diverse set of cognitive functions through interactions with other neurotransmitter systems including the dopaminergic and GABAergic systems.
摘要
纹状体是前脑的主要区域之一，强烈表达毒蕈碱和烟碱型乙酰胆碱受体。本文综述了关于纹状体胆碱能感受组织及其在各种认知功能中的作用的现有知识和我们的新发现。药理学和遗传学操作表明，纹状体中的胆碱能和多巴胺能系统相互调节彼此的功能。除了调节多巴胺能系统外，烟碱型乙酰胆碱受体还促进 GABA 的释放，而毒蕈碱型受体则减弱 GABA 的释放。纹状体胆碱能系统还与各种认知功能有关，包括程序性学习和维度内转换。综上所述，这些数据表明，纹状体中的胆碱能系统通过与包括多巴胺能和 GABA 能系统在内的其他神经递质系统相互作用，参与了一系列不同的认知功能。
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