许可证状态与用药错误之间的关系。
Association between licence status and medication errors.
机构信息
Academic Division of Child Health, University of Nottingham, The Medical School, Derbyshire Children's Hospital, Derby, UK.
出版信息
Arch Dis Child. 2011 Mar;96(3):305-6. doi: 10.1136/adc.2010.191940. Epub 2010 Dec 3.
BACKGROUND AND AIMS
Unlicensed and off label drug use in children is common and leads to well-recognised problems. This study aimed to determine whether a relationship exists between medication errors and licence status.
METHODS
Reports of errors in a UK children's hospital from 2004 to 2006 were analysed in terms of licence status and degree of harm and compared to the incidence of unlicensed and off label drug use in the hospital.
RESULTS
20 of 158 (13%) errors were considered to have caused moderate harm and 12 of these involved unlicensed/off label drugs. 138 (87%) caused no or low harm. None caused severe harm. Unlicensed drug usage was significantly more likely to be associated with errors than licensed use in both children and neonates.
CONCLUSION
Unlicensed drug use appears to be associated with medication errors in neonates and children. Medication errors causing moderate harm were significantly more likely to be associated with both unlicensed and off label than licensed drugs.
背景与目的
在儿童中使用未经许可和标签外的药物很常见，并且会导致众所周知的问题。本研究旨在确定药物错误与许可状态之间是否存在关系。
方法
分析了 2004 年至 2006 年期间英国一家儿童医院的药物错误报告，根据许可状态和伤害程度进行了分析，并与医院中未许可和标签外药物的使用发生率进行了比较。
结果
158 个错误中有 20 个（13%）被认为造成中度伤害，其中 12 个涉及未许可/标签外药物。138 个（87%）造成无或低伤害。没有造成严重伤害。在儿童和新生儿中，未许可药物的使用与错误的发生明显相关，而许可药物的使用则不然。
结论
未许可药物的使用似乎与新生儿和儿童的药物错误有关。造成中度伤害的药物错误与未许可和标签外药物的发生明显相关，而与许可药物的发生无关。
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