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[结直肠癌中的组学对接与分子分类]

[Omics docking and molecular classification in colorectal cancer].

作者信息

Peng Ya, Shen Shourong

机构信息

Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Nov;35(11):1201-6. doi: 10.3969/j.issn.1672-7347.2010.11.015.

Abstract

Omics docking has become a hot spot in oncology research, which is used to screen specific biomarkers for the establishment of molecular classification in the treatment and/or prognosis of diseases, especially in cancer research. Colorectal cancer (CRC) is one of the common malignant tumors, the traditional diagnosis and treatment of which depends on clinical manifestations, classic pathological and imaging examination. In clinical pathology, completely different fates and prognoses were observed in CRC patients with the same type, at the same stage, and even with the same treatment. It is critical to use the omics docking strategy to select molecular biomarkers for early diagnosis and to assess the prognosis of CRC, to further standardize molecular classification model, and to guide individual treatment of CRC.

摘要

组学对接已成为肿瘤学研究的热点,用于筛选特定生物标志物,以建立疾病治疗和/或预后的分子分类,尤其是在癌症研究中。结直肠癌(CRC)是常见的恶性肿瘤之一,其传统诊断和治疗依赖于临床表现、经典病理及影像学检查。在临床病理学中,观察到相同类型、相同分期甚至接受相同治疗的CRC患者有着截然不同的命运和预后。采用组学对接策略选择分子生物标志物用于CRC的早期诊断和评估预后、进一步规范分子分类模型并指导CRC的个体化治疗至关重要。

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