人κ轻链增强子中一个八聚体结合位点的鉴定。
Identification of an octamer-binding site in the human kappa light-chain enhancer.
作者信息
Nelms K, Van Ness B
机构信息
Institute of Human Genetics, University of Minnesota, Minneapolis 55455.
出版信息
Mol Cell Biol. 1990 Jul;10(7):3843-6. doi: 10.1128/mcb.10.7.3843-3846.1990.
Abstract
Octamer motifs contribute to the function and tissue specificity of immunoglobulin heavy- and light-chain gene promoters and the heavy-chain enhancer. A variant octamer-binding site within a conserved region of the human kappa light-chain gene enhancer which contributes to the function of this enhancer has been identified.
摘要
八聚体基序有助于免疫球蛋白重链和轻链基因启动子以及重链增强子的功能和组织特异性。已在人κ轻链基因增强子保守区域内鉴定出一个变体八聚体结合位点，该位点有助于此增强子的功能。
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