Mathies Alex K, Mattson Anita E, Scheidt Karl A
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
Synlett. 2009 Jan 1;2009(3):377-383. doi: 10.1055/s-0028-1087555.
The addition of acyl anion equivalents to aliphatic aldehydes (crossed-acyloin reaction) has been developed. Cesium fluoride with isopropanol as solvent promotes the addition of O-silyl thiazolium carbinols to various aliphatic aldehydes in moderate to good yields. These reactions represent a general procedure for the selective coupling of aliphatic aldehydes by an acyl anion reaction which have been problematic until now.
已开发出向脂肪醛中添加酰基阴离子等价物(交叉偶姻反应)的方法。以异丙醇为溶剂的氟化铯能促使O-硅烷基噻唑鎓甲醇与各种脂肪醛发生加成反应,产率适中至良好。这些反应代表了一种通过酰基阴离子反应选择性偶联脂肪醛的通用方法,而这种反应在此之前一直存在问题。