微波辅助合成磺酰氯和磺酰氟的磺酸盐前体
Microwave Assisted Synthesis of Sodium Sulfonates Precursors of Sulfonyl Chlorides and Fluorides.
作者信息
Alapafuja Shakiru O, Nikas Spyros P, Shukla Vidyanand G, Papanastasiou Ioannis, Makriyannis Alexandros
机构信息
Center for Drug Discovery, Northeastern University, 116 Mugar Life Sciences Building, 360 Huntington Avenue, Boston, MA, 02115, USA.
出版信息
Tetrahedron Lett. 2009 Dec 16;50(50):7028-7031. doi: 10.1016/j.tetlet.2009.09.167.
Abstract
We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase.
摘要
我们描述了一种微波反应，用于将各种溴化物转化为磺酸钠，这些磺酸钠已进一步转化为磺酰氯。这种新方法可提高产率并缩短反应时间。代表性的磺酰氯可作为相应磺酰氟的前体，而磺酰氟是脂肪酸酰胺水解酶的有效抑制剂。
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